Reactome | Active Flt3:Grb2 binds Gab2

Active Flt3:Grb2 binds Gab2

Stable Identifier

R-MMU-9606623

Type

Reaction [binding]

Species

Mus musculus

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Feline McDonough Sarcoma-like tyrosine kinase (Flt3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in the Flt3 receptor, which facilitates its dimerization and autophosphorylation. Once fully active, Flt3 receptors can associate with growth factor receptor-bound protein 2 (Grb2). Subsequently, Grb2-associated-binding protein 2 (Gab2) binds Grb2 (Zhang et al. 2000, Masson et al. 2009, Chonabayashi et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
19438505	A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival Masson, K, Sun, J, Khan, R, Liu, T, Rönnstrand, L	Br. J. Haematol.	2009
11027663	Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase Zhang, S, Broxmeyer, HE	Biochem. Biophys. Res. Commun.	2000
23168613	Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3 Ishikawa, T, Kawamata, S, Ohno, T, Chonabayashi, K, Hishizawa, M, Uchiyama, T, Nagai, Y, Takaori-Kondo, A	Leukemia	2013