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Active Flt3:Grb2:p-Y-Gab2 binds Ptpn11
Stable Identifier
R-MMU-9606789
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Feline McDonough Sarcoma-like tyrosine kinase (Flt3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in the Flt3 receptor, which facilitates its dimerization and autophosphorylation. Once fully active, Flt3 receptors can associate with growth factor receptor-bound protein 2 (Grb2), which then recruits Grb2-associated-binding protein 2 (Gab2). Consequently, Gab2 is phosphorylated and recruits tyrosine-protein phosphatase non-receptor type 11 (Ptpn11). The serine residue at position 623 in Gab2 is known to be involved in Ptpn11 binding (Zhang et al. 2000, Arnaud et al. 2004). The precise association mechanism of Gab2 and Ptpn11 is unclear. Interaction of Flt3 with Ptpn11 is known to trigger Stat5 activation in various pathological conditions.
Literature References
PubMed ID
Title
Journal
Year
11027663
Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase
Zhang, S
,
Broxmeyer, HE
Biochem. Biophys. Res. Commun.
2000
15356145
Phosphorylation of Grb2-associated binder 2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation
Bertoglio, J
,
Arnaud, M
,
Deon, C
,
Loyaux, D
,
Crouin, C
J. Immunol.
2004
Participants
Input
Active Flt3:Grb2:p-Y-Gab2 [plasma membrane]
(Mus musculus)
Ptpn11 [cytosol]
(Mus musculus)
Output
Active Flt3:Grb2:p-Y-Gab2:Ptpn11 [plasma membrane]
(Mus musculus)
Orthologous Events
Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 (Homo sapiens)
Authored
Varusai, TM (2019-01-14)
Reviewed
Traer, E (2019-05-03)
Joshi, S (2019-05-21)
Created
Varusai, TM (2018-04-25)
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