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p-Plins translocate from lipid droplet surface to cytosol
Stable Identifier
R-MMU-9613670
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol
,
lipid droplet
ReviewStatus
5/5
General
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Lipophagy is the process of autophagic degradation of lipid droplets into fatty acids. Lipid droplets are coated with perilipin (Plin) protiens and they need to be eliminated for the degradation of the lipids inside. Cytosolic Heat shock cognate 71 kDa protein (Hspa8) binds Plin2 and Plin3 on the lipid droplet surface. Subsequently, Prkaa2 binds and phosphorylates perilipins. Phosphorylated Plins dissociate from Prkaa2 and are believed to translocate to the cytosol (S Kaushik et al. 2015, S Kaushik et al. 2016). The translocation mechanism of Plins from lipid droplets to cytosol is unclear. Consequently, this event is considered as a black box.
Literature References
PubMed ID
Title
Journal
Year
26902588
AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA
Cuervo, AM
,
Kaushik, S
Autophagy
2016
25961502
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
Cuervo, AM
,
Kaushik, S
Nat. Cell Biol.
2015
Participants
Input
p-Plins:Hspa8 [lipid droplet]
(Mus musculus)
Output
p-Plins:Hspa8 [cytosol]
(Mus musculus)
Orthologous Events
p-PLINs translocate from lipid droplet surface to cytosol (Homo sapiens)
Authored
Varusai, TM (2019-11-08)
Reviewed
Metzakopian, E (2019-02-22)
Created
Varusai, TM (2018-07-17)
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