During emergency granulopoiesis triggered by bacterial infection, transcription of Cebpb is activated by the cytokines Csf2 (GM-CSF) and Csf3 (G-CSF): Csf2 acts via Csf2r and causes phosphorylation of Creb1 which then binds the promoter of the Cebpb gene (Hirai et al. 2013) while Csf3 acts via Csf3r and causes phosphorylation of Stat3 which also binds the promoter of the Cebpb gene (Zhang et al. 2010). Both phospho-Creb1 and phospho-Stat3 activate transcription of Cebpb (Zhang et al. 2010, Hirai et al. 2013).
Satake, S, Hirai, H, Matsusue, A, Kamio, N, Ashihara, E, Imanishi, J, Maekawa, T, Tenen, DG, Ogino, S, Kimura, N, Huang, G
Murray, PJ, Nguyen-Jackson, H, Panopoulos, AD, Li, HS, Zhang, H, Watowich, SS
© 2022 Reactome
