Reactome | Cebpb mRNA is translated to yield Cebpb protein

Cebpb mRNA is translated to yield Cebpb protein

Stable Identifier

R-MMU-9622513

Type

Reaction [omitted]

Species

Mus musculus

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

General

SBML | | PDF

SVG | | PPTX | SBGN

Cebpb mRNA is translated to yield Cebpb protein

Cytosolic ribosomes translate the Cebpb mRNA to yield Cebpb protein (Calkhoven et al. 2000. Guerzoni et al. 2006, Basu et al. 2011, Perino et al. 2014), which is then imported into the nucleus. Translation initiation at 3 different methionine codons produces 3 different isoforms: CEBPB-FL, CEBPB-LAP, and CEBPB-LIP (Calkhoven et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
16418324	Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells Guerzoni, C, Bardini, M, Mariani, SA, Ferrari-Amorotti, G, Neviani, P, Panno, ML, Zhang, Y, Martinez, R, Perrotti, D, Calabretta, B	Blood	2006
10921906	Translational control of C/EBPalpha and C/EBPbeta isoform expression Calkhoven, CF, Müller, C, Leutz, A	Genes Dev.	2000
25365223	TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation Perino, A, Pols, TW, Nomura, M, Stein, S, Pellicciari, R, Schoonjans, K	J. Clin. Invest.	2014
21804532	3'UTR elements inhibit Ras-induced C/EBPβ post-translational activation and senescence in tumour cells Basu, SK, Malik, R, Huggins, CJ, Lee, S, Sebastian, T, Sakchaisri, K, Quiñones, OA, Alvord, WG, Johnson, PF	EMBO J.	2011