Foxo1 and Sin3a:Hdac complex bind Gck gene promoter

Stable Identifier
R-MMU-9625109
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Foxo1 and Sin3a:Hdac complex bind Gck gene promoter
In mouse hepatocytes, Foxo1, together with transcriptional repressor Sin3a and histone deacetylases (Hdacs) of the I class, binds the promoter of the Gck gene, encoding glucokinase (Langlet et al. 2017).
Literature References
PubMed ID Title Journal Year
29056338 Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling

Wang, L, Norris, T, Johansson, A, Ericson, E, Buettner, C, Accili, D, Langlet, F, Haeusler, RA, Aizawa, K, Lindén, D, Cook, JR

Cell 2017
Participants
Input
Output
Orthologous Events
FOXO1 and SIN3A:HDAC complex bind GCK gene promoter (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-23)
Reviewed
Donlon, T  (2018-10-23)
Created
Orlic-Milacic, M  (2018-10-19)
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