Cebpa binds Myc gene:E2f1

Stable Identifier
R-MMU-9625589
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Cebpa binds Myc gene:E2f1

Cebpa interacts with E2f1 bound to promoters (Slomiany et al. 2000, Porse et al. 2001). Cebpa inhibits the transcriptional activation activity of E2f1. The N terminus of the p42 isoform of Cebpa is required for interaction with E2f factors (Porse et al. 2001) and therefore the p30 isoform, which lacks the N terminus, has a reduced ability to inhibit proliferation.

Literature References
PubMed ID Title Journal Year
11672531 E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

Pedersen, TA, Friis-Hansen, L, Xu, X, Nerlov, C, Wewer, UM, Porse, BT, Lindberg, B

Cell 2001
10913181 C/EBPalpha inhibits cell growth via direct repression of E2F-DP-mediated transcription

Slomiany, BA, D'Arigo, KL, Kurtz, DT, Kelly, MM

Mol. Cell. Biol. 2000
Participants
Orthologous Events
Authored
Reviewed
Created
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