Cebpa binds Myc gene:E2f1

Stable Identifier
R-MMU-9625589
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cebpa binds Myc gene:E2f1
Cebpa interacts with E2f1 bound to promoters (Slomiany et al. 2000, Porse et al. 2001). Cebpa inhibits the transcriptional activation activity of E2f1. The N terminus of the p42 isoform of Cebpa is required for interaction with E2f factors (Porse et al. 2001) and therefore the p30 isoform, which lacks the N terminus, has a reduced ability to inhibit proliferation.
Literature References
PubMed ID Title Journal Year
10913181 C/EBPalpha inhibits cell growth via direct repression of E2F-DP-mediated transcription

Slomiany, BA, D'Arigo, KL, Kurtz, DT, Kelly, MM

Mol. Cell. Biol. 2000
11672531 E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

Pedersen, TA, Friis-Hansen, L, Xu, X, Nerlov, C, Wewer, UM, Porse, BT, Lindberg, B

Cell 2001
Participants
Input
Output
Orthologous Events
CEBPA binds MYC gene:E2F1 (Homo sapiens)
Authored
May, B  (2018-10-21)
Reviewed
Skokowa, J  (2019-03-10)
Created
May, B  (2018-10-21)
Cite Us!