Myc gene expression is enhanced by E2f1, phospho-Stat3, and Cebpb and repressed by Cebpa

Stable Identifier
Reaction [BlackBoxEvent]
Mus musculus
SVG |   | PPTX  | SBGN
Myc gene expression is enhanced by E2f1, phospho-Stat3, and Cebpb and repressed by Cebpa

E2f1, phospho-Stat3, and Cebpb bind the promoter of the Myc gene and enhance transcription (Zhang et al. 2010) while Cebpa interacts with E2f1 to suppress transcription (Porse et al. 2001, Porse et al. 2005, Kowenz-Leutz et al. 2016). Cebpb reduces the residency of Cebpa at the Myc promoter (Zhang et al. 2010). Cebpb appears to inhibit expression of Myc less than Cebpa does, thus the ratio of Cebpb and Cebpa is believed to determine the proliferation (promoted by Cebpb) and differentiation (promoted by Cebpa) of neutrophil progenitors (Zhang et al. 2010).

Literature References
PubMed ID Title Journal Year
15983063 Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

Jacobsen, SE, Nerlov, C, Bryder, D, Anderson, K, Porse, BT, Hasemann, MS, Damgaard, I, Theilgaard-Mönch, K

J. Exp. Med. 2005
27131901 Functional interaction of CCAAT/enhancer-binding-protein-α basic region mutants with E2F transcription factors and DNA

Leutz, A, Knoblich, M, Schuetz, A, Liu, Q, Kowenz-Leutz, E, Heinemann, U

Biochim. Biophys. Acta 2016
11672531 E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

Pedersen, TA, Friis-Hansen, L, Xu, X, Nerlov, C, Wewer, UM, Porse, BT, Lindberg, B

Cell 2001
20581311 STAT3 controls myeloid progenitor growth during emergency granulopoiesis

Murray, PJ, Nguyen-Jackson, H, Panopoulos, AD, Li, HS, Zhang, H, Watowich, SS

Blood 2010
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