Ca2+ binds Kcnip3

Stable Identifier
R-MMU-9640094
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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 | PPTX  | SBGN
Ca2+ binds Kcnip3
Based on studies with mouse Kcnip3, Ca2+ binds to two high-affinity sites in Kcnip3 under physiological conditions, when magnesium is present. In the absence of magnesium, Ca2+ can bind to three sites in Kcnip3. Ca2+ does not disrupt Kcnip3 homotetramers but prevents their binding to target DNA sequences (Osawa et al. 2005).
Literature References
PubMed ID Title Journal Year
15746104 Mg2+ and Ca2+ differentially regulate DNA binding and dimerization of DREAM

Osawa, M, Dace, A, Ikura, M, Ames, JB, Valiveti, A, Tong, KI

J. Biol. Chem. 2005
Participants
Input
Output
Orthologous Events
Ca2+ binds KCNIP3 (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2019-03-20)
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