Expression of Trib3

Stable Identifier
R-MMU-9644327
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Trib3
The Trib3 (Trb3) gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Carraro et al. 2010, Huggins et al. 2015, Zhang et al. 2019). Expression of Trib3 is increased in response to amino acid deficiency (Carraro et al. 2010, Huggins et al. 2015) and heme deficiency (Zhang et al. 2019).
Literature References
PubMed ID Title Journal Year
21203563 Amino acid availability controls TRB3 transcription in liver through the GCN2/eIF2α/ATF4 pathway

Bruhat, A, Fafournoux, P, Carraro, V, Chaveroux, C, Lambert-Langlais, S, Jousse, C, Averous, J, Ord, T, Maurin, AC, Parry, L, Ord, D

PLoS ONE 2010
31033440 HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Macias-Garcia, A, Zhang, S, Butty, VL, Levine, SS, Sankaran, VG, Velazquez, J, Ulirsch, JC, Chen, JJ

Elife 2019
26667036 C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4

Haines, DC, Jailwala, P, Saylor, KL, Huggins, CJ, Quiñones, OA, Johnson, PF, Martin, N, Kasoji, M, Gonit, M, Mayekar, MK

Mol. Cell. Biol. 2015
Participants
Input
Output
This event is regulated
Positively by
Regulator
Atf4:Cebpg:Trib3 gene [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of TRIB3 in response to stress (Homo sapiens)
Authored
May, B  (2019-04-12)
Reviewed
Staschke, KA  (2019-11-20)
Chen, JJ  (2019-10-22)
Bruhat, A  (2019-09-15)
Created
May, B  (2019-04-12)
Cite Us!