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S-Farn-KRAS [endoplasmic reticulum membrane]
Stable Identifier
R-MMU-9647790
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
endoplasmic reticulum membrane
Synonyms
P32883
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS processing (Mus musculus)
ICMT methylates S-Farn RAS proteins (Mus musculus)
S-Farn-RAS [endoplasmic reticulum membrane] (Mus musculus)
S-Farn-KRAS [endoplasmic reticulum membrane] (Mus musculus)
RCE1 cleaves S-Farn proRAS proteins (Mus musculus)
S-Farn-RAS [endoplasmic reticulum membrane] (Mus musculus)
S-Farn-KRAS [endoplasmic reticulum membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:P32883 Kras
Gene Names
Kras, Kras2
Chain
chain:1-186, initiator methionine:, chain:2-186, propeptide:187-189
Reference Genes
BioGPS Gene:16653 Kras
KEGG:mmu:16653 Kras
Monarch:16653 Kras
NCBI Gene:16653 Kras
UCSC:P32883 Kras
Reference Transcript
RefSeq:XM_006506918.3 Kras
RefSeq:NM_021284.6 Kras
Other Identifiers
10549256
106672_at
106938_at
1426229_s_at
1434000_at
1441442_at
1451979_at
16653
17472725
4313059
4335609
4412753
4441411
4489978
4570800
4607066
4802038
4827993
4926216
5193962
5260598
5311146
5431855
5473122
97991_at
A_51_P136233
A_51_P377237
A_51_P509489
A_55_P2008591
GE32892
GO:0000166
GO:0003824
GO:0003924
GO:0003925
GO:0005515
GO:0005525
GO:0005737
GO:0005886
GO:0007010
GO:0007165
GO:0007265
GO:0008283
GO:0008542
GO:0009898
GO:0010467
GO:0010628
GO:0012501
GO:0012505
GO:0014009
GO:0016020
GO:0016601
GO:0016787
GO:0019002
GO:0019003
GO:0019221
GO:0021897
GO:0030036
GO:0030154
GO:0030275
GO:0030857
GO:0032228
GO:0035022
GO:0035914
GO:0043495
GO:0043524
GO:0044877
GO:0048009
GO:0048169
GO:0048856
GO:0048873
GO:0050877
GO:0051146
GO:0051402
GO:0060090
GO:0060252
GO:0060441
GO:0060509
GO:0098772
GO:2000774
ILMN_2773211
mMC023531
Participates
as a member of
S-Farn-RAS [endoplasmic reticulum membrane] (Mus musculus)
Other forms of this molecule
phospho-p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
Kras [plasma membrane]
phospho-pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane]
S-Farn-Me KRAS4A [plasma membrane]
S-Farn-Me PalmS KRAS4A [Golgi membrane]
proKRAS [cytosol]
pro-KRAS4A [cytosol]
S-Farn proKRAS4B [endoplasmic reticulum membrane]
S-Farn-proKRAS [endoplasmic reticulum membrane]
S-Farn-Me KRAS [endoplasmic reticulum membrane]
S-Farn KRAS4B [endoplasmic reticulum membrane]
S-Farn-Me KRAS4B [endoplasmic reticulum membrane]
phospho-pS181-S-Farn-Me KRAS4B [plasma membrane]
S-Farn-Me KRAS4B [cytosol]
S-Farn-Me-PalmS KRAS4A [plasma membrane]
S-Farn-Me KRAS4B [plasma membrane]
Inferred From
S-Farn-KRAS [endoplasmic reticulum membrane]
(Homo sapiens)
S-Farn KRAS4A [endoplasmic reticulum membrane]
(Homo sapiens)
Modified Residues
Name
S-farnesyl-L-cysteine at 186 (in Homo sapiens)
Coordinate
186
PsiMod Name
S-farnesyl-L-cysteine [MOD:00111]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine.
Cross References
RefSeq
NP_067259.4
,
XP_006506981.1
ENSEMBL
ENSMUST00000032399
,
ENSMUSP00000107339
,
ENSMUSP00000032399
,
ENSMUST00000111710
PRO
P32883
GlyGen
P32883
MGI
96680
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.573
2
UniProt:Q01279
6
phospho-p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-MMU-8869138)
phospho-p-4Y-EGFR [plasma membrane]
(R-MMU-180287)
phospho-p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane]
(R-MMU-8864019)
EGFR [plasma membrane]
(R-MMU-179837)
phospho-p-Y1086,Y1101-EGFR [plasma membrane]
(R-MMU-179868)
phospho-p-6Y-EGFR [plasma membrane]
(R-MMU-179803)
0.463
3
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