Kcnq4 transports K+ from the cytosol to the extracellular region

Stable Identifier
R-MMU-9659557
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Kcnq4 transports K+ from the cytosol to the extracellular region

Kcnq4 located on the basal membrane of outer hair cells (OHCs) (Kharkovets et al. 2000, Beisel et al. 2000, Kharkovets et al. 2006, Beisel et al. 2005, Winter et al. 2006) and inner hair cells (Kharkovets et al. 2000, Beisel et al. 2005) transports potassium ions along the concentration gradient from the cytosol to the extracellular region (Kharkovets et al. 2006). The resulting efflux of potassium is believed to be responsible for the I(K,n) current that plays a role in setting the resting potential of the cell and in repolarizing the cell (Oliver et al. 2003, Xu et al. 2007). Kcnq4 is located predominantlly in the basal membrane of OHCs (Kharkovets et al. 2000, Winter et al. 2006) and absence of Kcnq4 causes increased depolarization and degeneration of OHCs (Kharkovets et al. 2006).

Literature References
PubMed ID Title Journal Year
12657673 Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels

Fakler, B, Knipper, M, Oliver, D, Derst, C

J. Neurosci. 2003
10760300 KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway

El-Amraoui, A, Kharkovets, T, Safieddine, S, Jentsch, TJ, Hardelin, JP, Schweizer, M, Petit, C

Proc. Natl. Acad. Sci. U.S.A. 2000
16803873 Thyroid hormone receptors TRalpha1 and TRbeta differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells

Christ, S, Walsh, EJ, Knipper, M, Bauer, K, Rohbock, K, McGee, J, Geisler, HS, Zimmermann, U, Köpschall, I, Knirsch, M, Engel, J, Winter, H, Weber, T, Fränzer, JT, Braig, C, Ley, M

J. Cell. Sci. 2006
11042367 Longitudinal gradients of KCNQ4 expression in spiral ganglion and cochlear hair cells correlate with progressive hearing loss in DFNA2

Nelson, NC, Fritzsch, B, Delimont, DC, Beisel, KW

Brain Res. Mol. Brain Res. 2000
16437162 Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness

Kharkovets, T, Dedek, K, Maier, H, Nouvian, R, Moser, T, Leuwer, R, Schweizer, M, Khimich, D, Jentsch, TJ, Vardanyan, V

EMBO J. 2006
16207888 Differential expression of KCNQ4 in inner hair cells and sensory neurons is the basis of progressive high-frequency hearing loss

Morris, KA, Feng, F, Rocha-Sanchez, SM, Fritzsch, B, Nie, L, Yamoah, EN, Kachar, B, Beisel, KW

J. Neurosci. 2005
17561493 Roles of alternative splicing in the functional properties of inner ear-specific KCNQ4 channels

Feng, W, Nie, L, Wei, D, Yamoah, EN, Mo, J, Zhang, Y, Xu, T, Kachar, B, Vazquez, AE, Petrov, E, Beisel, KW, Calisto, LE

J. Biol. Chem. 2007
Participants
Input
Catalyst Activity

voltage-gated potassium channel activity of Kcnq4 tetramer [plasma membrane]

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