Outer hair cell stereocilium tip [cytosol]

Stable Identifier
Mus musculus
Literature References
PubMed ID Title Journal Year
26754646 Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth

Lelli, A, Michel, V, Boutet de Monvel, J, Cortese, M, Bosch-Grau, M, Aghaie, A, Perfettini, I, Dupont, T, Avan, P, El-Amraoui, A, Petit, C

J. Cell Biol. 2016
12807912 Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated

Vartiainen, MK, Sarkkinen, EM, Matilainen, T, Salminen, M, Lappalainen, P

J. Biol. Chem. 2003
19287378 Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments

Salles, FT, Merritt, RC, Manor, U, Dougherty, GW, Sousa, AD, Moore, JE, Yengo, CM, Dose, AC, Kachar, B

Nat. Cell Biol. 2009
21526224 Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells

Zampini, V, Rüttiger, L, Johnson, SL, Franz, C, Furness, DN, Waldhaus, J, Xiong, H, Hackney, CM, Holley, MC, Offenhauser, N, Di Fiore, PP, Knipper, M, Masetto, S, Marcotti, W

PLoS Biol. 2011
22264607 Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions

Merritt, RC, Manor, U, Salles, FT, Grati, M, Dose, AC, Unrath, WC, Quintero, OA, Yengo, CM, Kachar, B

Curr. Biol. 2012
19853587 Protein 4.1 expression in the developing hair cells of the mouse inner ear

Okumura, K, Mochizuki, E, Yokohama, M, Yamakawa, H, Shitara, H, Mburu, P, Yonekawa, H, Brown, SD, Kikkawa, Y

Brain Res. 2010
26926603 Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like

Ebrahim, S, Avenarius, MR, Grati, M, Krey, JF, Windsor, AM, Sousa, AD, Ballesteros, A, Cui, R, Millis, BA, Salles, FT, Baird, MA, Davidson, MW, Jones, SM, Choi, D, Dong, L, Raval, MH, Yengo, CM, Barr-Gillespie, PG, Kachar, B

Nat Commun 2016
23918390 Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2

Furness, DN, Johnson, SL, Manor, U, Rüttiger, L, Tocchetti, A, Offenhauser, N, Olt, J, Goodyear, RJ, Vijayakumar, S, Dai, Y, Hackney, CM, Franz, C, Di Fiore, PP, Masetto, S, Jones, SM, Knipper, M, Holley, MC, Richardson, GP, Kachar, B, Marcotti, W

Proc. Natl. Acad. Sci. U.S.A. 2013
20661277 Gelsolin plays a role in the actin polymerization complex of hair cell stereocilia

Mburu, P, Romero, MR, Hilton, H, Parker, A, Townsend, S, Kikkawa, Y, Brown, SD

PLoS ONE 2010
26307081 Distinct expression and function of whirlin isoforms in the inner ear and retina: an insight into pathogenesis of USH2D and DFNB31

Mathur, PD, Zou, J, Zheng, T, Almishaal, A, Wang, Y, Chen, Q, Wang, L, Vashist, D, Brown, S, Park, A, Yang, J

Hum. Mol. Genet. 2015
24475274 The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells

Olt, J, Mburu, P, Johnson, SL, Parker, A, Kuhn, S, Bowl, M, Marcotti, W, Brown, SD

PLoS ONE 2014
19774077 MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear

Rzadzinska, AK, Nevalainen, EM, Prosser, HM, Lappalainen, P, Steel, KP

PLoS ONE 2009
16829577 Whirlin complexes with p55 at the stereocilia tip during hair cell development

Mburu, P, Kikkawa, Y, Townsend, S, Romero, R, Yonekawa, H, Brown, SD

Proc. Natl. Acad. Sci. U.S.A. 2006
30618612 Inactivation of Cyclin-Dependent Kinase 5 in Hair Cells Causes Hearing Loss in Mice

Zhai, X, Liu, C, Zhao, B, Wang, Y, Xu, Z

Front Mol Neurosci 2018
15314067 Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia

Kitajiri, S, Fukumoto, K, Hata, M, Sasaki, H, Katsuno, T, Nakagawa, T, Ito, J, Tsukita, S, Tsukita, S

J. Cell Biol. 2004
19955359 Twinfilin 2 regulates actin filament lengths in cochlear stereocilia

Peng, AW, Belyantseva, IA, Hsu, PD, Friedman, TB, Heller, S

J. Neurosci. 2009
21236676 Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8

Manor, U, Disanza, A, Grati, M, Andrade, L, Lin, H, Di Fiore, PP, Scita, G, Kachar, B

Curr. Biol. 2011
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