Kcnn2 transports K+ from the cytosol to the extracellular region

Stable Identifier
R-MMU-9663768
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Kcnn2 transports K+ from the cytosol to the extracellular region

Small potassium current channels (SK2 channels, Kcnn2 tetramers) in outer hair cells (OHCs) open in response to cytosolic calcium and transport potassium ions from the cytosol to the extracellular region, resulting in hyperpolarization and inhibition of contraction of the OHC (Kong et al. 2008, Maison et al. 2013).

Literature References
PubMed ID Title Journal Year
18818242 Expression of the SK2 calcium-activated potassium channel is required for cholinergic function in mouse cochlear hair cells

Adelman, JP, Kong, JH, Fuchs, PA

J. Physiol. (Lond.) 2008
23282326 Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea

Liberman, MC, Pyott, SJ, Meredith, AL, Maison, SF

J. Neurophysiol. 2013
Participants
Input
Catalyst Activity

calcium-activated potassium channel activity of Kcnn2 tetramer [plasma membrane]

Orthologous Events
Authored
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