Nbr1 translocates from cytosol to perixosomal membrane

Stable Identifier
R-MMU-9666410
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, peroxisomal membrane
ReviewStatus
5/5
General
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Nbr1 translocates from cytosol to perixosomal membrane
Molecular oxygen regulates the translocation of the autophagy receptor Next to BRCA1 gene 1 protein (Nbr1) from the cytosol to the peroxisomal membrane. Low oxygen stimulates Endothelial PAS domain containing protein 1 (Epas1), which positively regulates the translocation of Nbr1 (Walter KM et al. 2014).
Literature References
PubMed ID Title Journal Year
25440060 Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy

Kovacs, WJ, Walter, KM, Trötzmüller, M, Krek, W, Moser, AB, Lucas, MS, Köfeler, HC, Moch, H, Faust, PL, Schönenberger, MJ, Elsässer, HP, Gerber, PA, Horn, M, Schwarz, T

Cell Metab. 2014
Participants
Input
Output
This event is regulated
Positively by
Regulator
Epas1 [cytosol] (Mus musculus)
Orthologous Events
NBR1 translocates from cytosol to perixosomal membrane (Homo sapiens)
Authored
Varusai, TM  (2019-11-04)
Reviewed
Metzakopian, E  (2019-10-30)
Created
Varusai, TM  (2019-11-05)
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