Nbea translocates to the nucleus

Stable Identifier
R-MMU-9667642
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Nbea translocates to the nucleus
Based on studies conducted in a mouse neuroblastoma cell line Neuro2a, on either endogenous or recombinant mouse neurobeachin (Nbea), it was found that Nbea was largely present in the cytoplasmic fraction of the cell, but a small portion of Nbea was nuclear. A nuclear localization signal (NLS) was mapped to the domain of unknown function (DUF1088) of Nbea and was shown to play a role in translocation to the nucleus (Tuand et al. 2016).
Literature References
PubMed ID Title Journal Year
26999814 Nuclear Localization of the Autism Candidate Gene Neurobeachin and Functional Interaction with the NOTCH1 Intracellular Domain Indicate a Role in Regulating Transcription

Meulemans, S, Creemers, J, Tuand, K, Volders, K, Nuytens, K, Declercq, J, Stijnen, P

PLoS ONE 2016
Participants
Input
Output
Orthologous Events
NBEA translocates to the nucleus (Homo sapiens)
Authored
Orlic-Milacic, M  (2020-01-07)
Reviewed
Miller, AC  (2020-02-10)
Martin, EA  (2020-02-10)
Created
Orlic-Milacic, M  (2019-11-14)
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