Nbea binds nicd1

Stable Identifier
R-MMU-9667655
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Nbea binds nicd1

Based on experiments conducted in a mouse neuroblastoma cell line Neuro2a (N2a), with the use of recombinant mouse Nbea and Notch1, it was found that the DPBW module of Nbea, which consists of DUF1088, PH-like, and BEACH domains, and WD40 repeats, binds to Notch1 intracellular domain (nicd1). Nbea may negatively regulates transcription of Notch1 target genes, but experimental data is inconclusive (Tuand et al. 2016).

Literature References
PubMed ID Title Journal Year
26999814 Nuclear Localization of the Autism Candidate Gene Neurobeachin and Functional Interaction with the NOTCH1 Intracellular Domain Indicate a Role in Regulating Transcription

Meulemans, S, Creemers, J, Tuand, K, Volders, K, Nuytens, K, Declercq, J, Stijnen, P

PLoS ONE 2016
Participants
Orthologous Events
Authored
Reviewed
Created
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