Reactome | Kcnma1:Kcnmb1:Lrrc52 transports potassium ions from the cytosol to the extracellular region

Kcnma1:Kcnmb1:Lrrc52 transports potassium ions from the cytosol to the extracellular region

Stable Identifier

R-MMU-9667756

Type

Reaction [transition]

Species

Mus musculus

Compartment

plasma membrane

ReviewStatus

5/5

General

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Kcnma1:Kcnmb1:Lrrc52 transports potassium ions from the cytosol to the extracellular region

BK potassium channels (Kcnma1:Kcnmb1) are complexed with Lrrc52 in Inner Hair Cells (IHCs) (Lang et al. 2019, Lingle et al. 2019), which renders the channels sensitive to voltage but insensitive to calcium ions (Lang et al. 2019, Lingle et al. 2019). In response to depolarization of the cell caused by opening of the mechanoelectrical transduction (MET) channel, Kcnma1:Kcnmb1:Lrrc52 channels located in the collar region of the IHC open and transport potassium ions out of the cell, thereby participating in the repolarization of the IHC (Lang et al. 2019, Lingle et al. 2019.

Literature References

PubMed ID	Title	Journal	Year
31451634	LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells Yang-Hood, A, V-Ghaffari, B, Rutherford, MA, Payne, S, Pyott, SJ, Xia, XM, Persic, D, Boero, LE, Zhou, Y, Xiao, M, Martinez-Espinosa, PL, Lingle, CJ	Proc. Natl. Acad. Sci. U.S.A.	2019
31348683	Expression of the LRRC52 γ subunit (γ2) may provide Ca²⁺-independent activation of BK currents in mouse inner hair cells Jung, M, Engel, J, Niemeyer, BA, Ruth, P, Lang, I	FASEB J.	2019