p-Y-Jak1 phosphorylates Csf3r in Csf3 dimer:2xCsf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2

Stable Identifier
R-MMU-9674921
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-Y-Jak1 phosphorylates Csf3r in Csf3 dimer:2xCsf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2
The cytosolic domain of Csf3r is phosphorylated (Pan et al. 1993) by Jak1 (Shimoda et al. 1997).
Literature References
PubMed ID Title Journal Year
9226159 Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor

Shimoda, K, Feng, J, Murakami, H, Nagata, S, Watling, D, Rogers, NC, Stark, GR, Kerr, IM, Ihle, JN

Blood 1997
7503988 Unidirectional cross-phosphorylation between the granulocyte colony-stimulating factor and interleukin 3 receptors

Pan, CX, Fukunaga, R, Yonehara, S, Nagata, S

J. Biol. Chem. 1993
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Csf3 dimer:2xCsf3r:Lyn:p-Y-Jak1 [plasma membrane]

Physical Entity
Csf3 dimer:2xCsf3r:Lyn:p-Y-Jak1 [plasma membrane] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
p-Y-JAK1 phosphorylates CSF3R in CSF3 dimer:2xCSF3R:LYN:p-Y-JAK1 (Homo sapiens)
Authored
May, B  (2020-01-27)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-01-29)
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