Reactome | Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 dissociates yielding Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 and p-Y-Stat1,3,5

Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 dissociates yielding Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 and p-Y-Stat1,3,5

Stable Identifier

R-MMU-9674931

Type

Reaction [dissociation]

Species

Mus musculus

Compartment

plasma membrane

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 dissociates yielding Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 and p-Y-Stat1,3,5

After phosphorylation while bound to phospho-Csf3r at the plasma membrane, p-Stat1,3,5 dissociates from Csf3r prior to dimerizing and transiting to the nucleus (Nicholson et al. 1995, de Koning et al. 1996, Nicholson et al. 1996, Gits et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
7579336	Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK Novak, U, Layton, JE, Nicholson, SE, Ziegler, SF	Blood	1995
8900180	Tyrosine residues in the granulocyte colony-stimulating factor (G-CSF) receptor mediate G-CSF-induced differentiation of murine myeloid leukemic (M1) cells Novak, U, Layton, JE, Nicholson, SE, Hilton, DJ, Starr, R	J. Biol. Chem.	1996
8608222	The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation van der Plas, DC, Schelen, AM, Barge, RM, Smith, L, Touw, IP, Löwenberg, B, Dong, F, de Koning, JP, Hoefsloot, LH	Blood	1996
17066093	Multiple pathways contribute to the hyperproliferative responses from truncated granulocyte colony-stimulating factor receptors Ward, AC, Touw, IP, Carroll, HP, van Leeuwen, D, Gits, J	Leukemia	2006

Participants

Input

Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:p-Y-Stat1,3,5 [plasma membrane] (Mus musculus)

Output

Orthologous Events

CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-STAT1,3,5 dissociates yielding CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 and p-Y-STAT1,3,5 (Homo sapiens)

Authored

May, B (2020-01-27)

Reviewed

Touw, IP (2020-12-12)

Created

May, B (2020-01-29)

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