Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Stat1,3,5

Stable Identifier
R-MMU-9674959
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Stat1,3,5
The Stat proteins Stat1 (de Koning et al 1996, Nicholson et al. 1996), Stat3 (de Koning et al. 1996, Nicholson et al. 1996, Chakraborty et al. 1999, Ward et al. 1999, de Koning et al. 2000), and Stat5 (Stat5a and Stat5b) (Nicholson et al. 1996) bind phosphotyrosines of the cytosolic domain of Csf3r. A mechanism for Stat activation that is independent of phosphotyrosines may also exist (Nicholson et al. 1996).
Literature References
PubMed ID Title Journal Year
8900180 Tyrosine residues in the granulocyte colony-stimulating factor (G-CSF) receptor mediate G-CSF-induced differentiation of murine myeloid leukemic (M1) cells

Novak, U, Layton, JE, Nicholson, SE, Hilton, DJ, Starr, R

J. Biol. Chem. 1996
10918585 STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1)

Schelen, AM, Ward, AC, Touw, IP, Löwenberg, B, van Leeuwen, D, de Koning, JP, Soede-Bobok, AA, Antonissen, C

Oncogene 2000
10329697 Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells

Smith, L, Ward, AC, Touw, IP, van Aesch, Y, de Koning, JP

J. Biol. Chem. 1999
8608222 The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation

van der Plas, DC, Schelen, AM, Barge, RM, Smith, L, Touw, IP, Löwenberg, B, Dong, F, de Koning, JP, Hoefsloot, LH

Blood 1996
9864141 Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor

Tweardy, DJ, Dyer, KF, Chakraborty, A, Cascio, M, Mietzner, TA

Blood 1999
Participants
Input
Output
Orthologous Events
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds STAT1,3,5 (Homo sapiens)
Authored
May, B  (2020-01-27)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-01-29)
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