Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2

Stable Identifier
R-MMU-9676072
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
plasma membrane
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1 binds and activates Jak2, Syk, Hck, and Tyk2

The kinases Jak2 (Nicholson et al. 1995, Avalos et al. 1997), Tyk2 (Novak et al. 1996, Avalos et al. 1997), Hck (Ward et al. 1998, Santini et al. 2003), and Syk (Corey et al. 1994, Santini et al. 2003) bind phosphorylated tyrosine residues of the cytosolic domain of Csf3r and are activated by phosphorylation.

Literature References
PubMed ID Title Journal Year
7579336 Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK

Novak, U, Layton, JE, Nicholson, SE, Ziegler, SF

Blood 1995
9790917 The Src-like tyrosine kinase Hck is activated by granulocyte colony-stimulating factor (G-CSF) and docks to the activated G-CSF receptor

Ward, AC, Touw, IP, Bello, PA, Csar, XF, Monkhouse, JL

Biochem. Biophys. Res. Commun. 1998
12586631 The carboxy-terminal region of the granulocyte colony-stimulating factor receptor transduces a phagocytic signal

Gozzini, A, Schreiber, AD, Indik, ZK, Scappini, B, Santini, V, Ferrini, PR

Blood 2003
9015216 Dissociation of the Jak kinase pathway from G-CSF receptor signaling in neutrophils

Avalos, BR, Druker, BJ, Sibert, KA, Hunter, MG, Ware, DA, Parker, JM

Exp. Hematol. 1997
8197119 Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases

Corey, SJ, Tweardy, DJ, Bolen, JB, Tkatch, LS, Burkhardt, AL, Geahlen, RL

Proc. Natl. Acad. Sci. U.S.A. 1994
8919032 Aberrant activation of JAK/STAT pathway components in response to G-CSF, interferon-alpha/beta and interferon-gamma in NFS-60 cells

Ward, AC, Novak, U, Hamilton, JA, Hertzog, PJ, Paradiso, L

Growth Factors 1996
Participants
Input
Output
Orthologous Events
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)
Authored
May, B  (2020-01-29)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-02-06)
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