Reactome | Grap2 [cytosol]

Grap2 [cytosol]

Stable Identifier

R-MMU-9680624

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

GRB2-related adaptor protein 2, GRAP2_MOUSE

External Reference Information

External Reference

UniProt:O89100 Grap2

Gene Names

Grap2, Gads, Grb2l, Grid, Mona

Chain

chain:1-322

Reference Genes

BioGPS Gene:17444 Grap2

ENSEMBL:ENSMUSG00000042351.10 Grap2

KEGG Gene (Mus musculus):17444 Grap2

Monarch:17444 Grap2

NCBI Gene:17444 Grap2

UCSC:O89100 Grap2

Reference Transcript

Other Identifiers

102633_at

10425410

1420685_at

1460280_at

17313147

17444

4364713

4459336

4495518

4652221

4662234

4782509

4899922

4994215

5087101

5181111

5205719

5260784

5277011

5537125

5586648

A_52_P120612

A_52_P150683

GE119100

GO:0001784

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0005886

GO:0007165

GO:0023052

GO:0031410

GO:0043226

GO:0043408

ILMN_1218749

ILMN_2711241

ILMN_2711242

ILMN_3113787

mMC007464

mMC021078

Participates

as a component of

Csf1 dimer:PolyUb,p-8Y-Csf1r dimer:Fyn,Hck,Src,Yes1:p-Y-Gab2:p-Y-Gab3:Grap2:Inpp5d:Inppl1:Pi3k:Ptpn11:p-Y-Shc1:p-Y-Plcg2 [plasma membrane] (Mus musculus)

as an input of

Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated (Mus musculus)

Other forms of this molecule

Grap2 [cytosol]

Cross References

RefSeq

NP_034945.1, NP_001276371.1

Ensembl

ENSMUSP00000155681, ENSMUSP00000046532, ENSMUST00000043149, ENSMUST00000229980, ENSMUSG00000042351

PRO

O89100

MGI

1333842

PDB

1UTI, 1R1Q, 2W10, 1OEB, 2D0N, 1R1S, 1R1P, 1H3H

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.835	7
UniProt:P40818 USP8	2	USP8 [cytosol] (R-HSA-917720) p-T945-USP8 [cytosol] (R-HSA-1358714)	0.75	4
UniProt:Q9QUN3	2	Blnk [cytosol] (R-MMU-912750) phospho-Blnk [plasma membrane] (R-MMU-983579)	0.658	4
UniProt:Q6PB44 PTN23			0.618	3
UniProt:O35601 Fyb	2	Adap [cytosol] (R-MMU-430207) Fyb1 [cytosol] (R-MMU-390925)	0.611	3
UniProt:Q8WV28 BLNK	2	BLNK [cytosol] (R-HSA-912750) p-5Y-BLNK [plasma membrane] (R-HSA-983579)	0.609	2
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.602	3
UniProt:P70218 M4K1			0.558	2
UniProt:Q80U87	2	Usp8 [cytosol] (R-MMU-917720) phospho-Usp8 [cytosol] (R-MMU-1358714)	0.544	4
UniProt:Q60787 Lcp2	2	SLP-76 [cytosol] (R-MMU-430203) phospho-Lcp2 [cytosol] (R-MMU-202175)	0.499	7
UniProt:P09581 Csf1r	5	p-Y559-Csf1r [plasma membrane] (R-MMU-9763882) PolyUb,p-8Y-Csf1r [plasma membrane] (R-MMU-9680640) K48polyUb,p-Y559-Csf1r [plasma membrane] (R-MMU-9763897) Csf1r [plasma membrane] (R-MMU-9680626) CSF1R [plasma membrane] (R-MMU-197667)	0.482	2

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