Expression of Dmrt1 in testis differentiation

Stable Identifier
R-MMU-9690898
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Dmrt1 in testis differentiation
The Dmrt1 gene is transcribed to yield mRNA and the mRNA is translated to yield Dmrt1 protein (Lei and Heckert 2004, Manuylov et al. 2011, Barrionuevo et al. 2016). Sox9 and Gata4 bind the promoter of the Dmrt1 gene and activate transcription of Dmrt1 (Lei and Heckert 2004, Manuylov et al. 2011, Barrionuevo et al. 2016).
Literature References
PubMed ID Title Journal Year
21385577 Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation

Pu, WT, Ma, Q, Zhou, B, Manuylov, NL, Fox, SC, Tevosian, SG

Dev. Biol. 2011
14673170 Gata4 regulates testis expression of Dmrt1

Heckert, LL, Lei, N

Mol. Cell. Biol. 2004
27328324 Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration

Jiménez, R, Barrionuevo, FJ, Burgos, M, Hurtado, A, Kopp, JL, Kim, GJ, Scherer, G, Bakkali, M, Sander, M, Real, FM

Elife 2016
Participants
Input
Output
This event is regulated
Positively by
Regulator
Sox9:Gata4:Dmrt1 gene [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of DMRT1 in testis differentiation (Homo sapiens)
Authored
May, B  (2020-05-31)
Reviewed
Imaimatsu, K  (2020-10-29)
Kanai, Y  (2020-10-29)
Created
May, B  (2020-06-06)
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