The transcription factors Wt1 (Miyamoto et al. 2008), Nr5a1 (SF1), Gata4:Zfpm2 (Gata4:Fog2, Miyamoto et al. 2008, Gierl et al. 2012) bind the promoter of the Sry gene and activate transcription of Sry. Sry is a mammal-specific gene located on the Y chromosome that is responsible for male sex determination.