p-Y-Stat1,3,5 dimer enhances expression of Socs1

Stable Identifier
R-MMU-9705455
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-Y-Stat1,3,5 dimer enhances expression of Socs1
The Socs1 gene is transcribed to yield mRNA and the mRNA is translated to yield Socs1 protein. Stat1 dimers (Saito et al. 2000, Chan et al. 2014), Stat3 dimers (Naka et al. 1997), or Stat5 dimers (inferred from Stat1 and Stat3) presumed to be bound to the promoter of the Socs1 gene activate transcription of Socs1.
Literature References
PubMed ID Title Journal Year
24037089 Dysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERĪ±(+) tumorigenesis

Bhattacharya, D, Rickert, CG, Archambault, J, Vermi, W, White, JM, Lonardi, S, Allred, DC, Sheehan, KC, Arthur, C, Chan, SR, Schreiber, RD, Allen, JA, McDevitt, TM, Lorenzi, MV

Cell Death Differ 2014
10820262 IFN regulatory factor-1-mediated transcriptional activation of mouse STAT-induced STAT inhibitor-1 gene promoter by IFN-gamma

Kishimoto, T, Narazaki, M, Morita, Y, Fujimoto, M, Saito, H, Naka, T

J Immunol 2000
9202127 Structure and function of a new STAT-induced STAT inhibitor

Kajita, T, Kishimoto, T, Aono, A, Yoshizaki, K, Nishimoto, N, Matsumoto, T, Narazaki, M, Minamoto, S, Hirata, M, Akira, S, Taga, T, Naka, T

Nature 1997
Participants
Input
Output
This event is regulated
Positively by
Regulator
p-Y-Stat1,3,5 dimer:Socs1 gene [nucleoplasm] (Mus musculus)
Orthologous Events
p-Y-STAT1,3,5 dimer enhances expression of SOCS1 (Homo sapiens)
Authored
May, B  (2020-10-18)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-10-24)
Cite Us!