p-Y-Stat1,3,5 dimer binds Socs3 gene

Stable Identifier
R-MMU-9705459
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-Y-Stat1,3,5 dimer binds Socs3 gene
Stat1 (Auernhammer et al. 1999, Gatto et al. 2004), Stat3 (Auernhammer et al. 1999, Hou et al. 2008), and Stat5 (Emanuelli et al. 2000) dimers bind the 5' region of the Socs3 gene.
Literature References
PubMed ID Title Journal Year
18782771 The STAT3 NH2-terminal domain stabilizes enhanceosome assembly by interacting with the p300 bromodomain

Lee, C, Brasier, AR, Ray, S, Hou, T

J Biol Chem 2008
14742442 Analysis of SOCS-3 promoter responses to interferon gamma

Tininini, S, Berlato, C, Cassatella, MA, Poli, V, Gatto, L, Kinjyo, I, Bazzoni, F, Yoshimura, A

J. Biol. Chem. 2004
10821852 SOCS-3 is an insulin-induced negative regulator of insulin signaling

Sawka-Verhelle, D, Peraldi, P, Hilton, D, Filloux, C, Van Obberghen, E, Emanuelli, B

J Biol Chem 2000
10359822 Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter

Bousquet, C, Auernhammer, CJ, Melmed, S

Proc Natl Acad Sci U S A 1999
Participants
Input
Output
Orthologous Events
p-Y-STAT1,3,5 dimer binds SOCS3 gene (Homo sapiens)
Authored
May, B  (2020-10-18)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-10-24)
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