Socs1,3 binds p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2

Stable Identifier
R-MMU-9705471
Type
Reaction [binding]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Socs1,3 binds p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2
Socs3 or Socs1 binds phosphotyrosine-729 (phosphotyrosine-728 of isoform 1) of Csf3r (Hermans et al. 2003, van de Geijn et al. 2004, Zhuang et al . 2005).
Literature References
PubMed ID Title Journal Year
16033816 Tyrosine 729 of the G-CSF receptor controls the duration of receptor signaling: involvement of SOCS3 and SOCS1

Haque, SJ, Qiu, Y, Dong, F, Zhuang, D

J Leukoc Biol 2005
15069015 G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact

Aarts, LH, Gits, J, Heijmans-Antonissen, C, van de Geijn, GJ, Touw, IP

Blood 2004
12468431 Signaling mechanisms coupled to tyrosines in the granulocyte colony-stimulating factor receptor orchestrate G-CSF-induced expansion of myeloid progenitor cells

Hermans, MH, Antonissen, C, Gits, J, van de Geijn, GJ, Ward, AC, Touw, IP, van Leeuwen, D

Blood 2003
Participants
Orthologous Events
Authored
Reviewed
Created
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