Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Cul5, EloB, EloC, and Rnf7

Stable Identifier
R-MMU-9707972
Type
Reaction [binding]
Species
Mus musculus
Compartment
endocytic vesicle membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Socs1,3:p-4Y-Csf3r:Csf3 dimer:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2 binds Cul5, EloB, EloC, and Rnf7
Socs1 and Socs3 recruit Elongin B (Elob), Elongin C (Eloc), Cullin5 (Cul5), and Rnf7 to form a ubiquitin E3 ligase complex (Babon et al. 2008, Babon et al. 2009, Kershaw et al. 2014). Socs3 has 100-fold higher affinity for Cul5 than Socs1 has (Babon et al. 2009).
Literature References
PubMed ID Title Journal Year
24438103 Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates

Kershaw, NJ, Laktyushin, A, Babon, JJ, Nicola, NA

Growth Factors 2014
19385048 The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression

Norton, RS, Zhang, JG, Babon, JJ, Nicola, NA, Sabo, JK

J Mol Biol 2009
18590740 The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase

Yao, S, Soetopo, A, Norton, RS, Bailey, MF, Zhang, JG, Babon, JJ, Nicola, NA, Sabo, JK

J Mol Biol 2008
Participants
Input
Output
Orthologous Events
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)
Authored
May, B  (2020-11-09)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-11-21)
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