cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol

Stable Identifier
R-MMU-9713672
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol
The olfactory cyclic nucleotide-gated channel (CNG channel) translocates sodium and calcium cations (Na+, Ca2+) from the extracellular region to the cytosol (Michalakis et al. 2006, Reisert et al. 2007, Nakashima et al. 2020).
Literature References
PubMed ID Title Journal Year
17932148 Olfactory marker protein modulates the cAMP kinetics of the odour-induced response in cilia of mouse olfactory receptor neurons

Yau, KW, Reisert, J, Margolis, FL

J Physiol 2007
32703433 Olfactory marker protein captures cAMP produced via Gαs-protein-coupled receptor activation

Nakashima, N, Takano, M, Nakashima, A, Nakashima, K

Biochem Biophys Res Commun 2020
16980309 Loss of CNGB1 protein leads to olfactory dysfunction and subciliary cyclic nucleotide-gated channel trapping

Reisert, J, Pfeifer, A, Biel, M, Bradley, J, Yau, KW, Wetzel, C, Michalakis, S, Gerstner, A, Geiger, H, Hatt, H, Zong, X, Hüttl, S, Spehr, M

J Biol Chem 2006
Participants
Input
Output
Catalyst Activity

monoatomic cation channel activity of cAMP:Olfactory CNG channel [plasma membrane]

Physical Entity
cAMP:Olfactory CNG channel [plasma membrane] (Mus musculus)
Activity
monoatomic cation channel activity (GO:0005261)
Orthologous Events
cAMP:olfactory CNG channel translocates Na+ and Ca2+ from the extracellular region to the cytosol (Homo sapiens)
Authored
May, B  (2021-01-26)
Reviewed
Raimondi, F  (2021-08-02)
Created
May, B  (2021-01-31)
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