Scn9a:Scn1b,2b,4b transports Na+ from the extracellular region to the cytosol

Stable Identifier
R-MMU-9717440
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Scn9a:Scn1b,2b,4b transports Na+ from the extracellular region to the cytosol

Scn9a in combination with a regulatory beta subunit responds to depolarization by opening and passively transporting sodium ions according to the concentration gradient from the extracellular region to the cytosol (Gao et al. 2009). In mouse type II taste cells, initial depolarization at the apex of the cell is believed to cause an activation potential via Scn2a, Scn3a, and Scn9a located at the basolateral membrane (Gao et al. 2009). Beta units Scn1b, Scn2b, and Scn4b are expressed in taste cells (Shandilya et al. 2016).

Literature References
PubMed ID Title Journal Year
27787515 AP1 transcription factors are required to maintain the peripheral taste system

Medler, KF, Roberts, SG, Nayak, TK, Gao, Y, Shandilya, J

Cell Death Dis 2016
19284629 Voltage-gated sodium channels in taste bud cells

Williams, ME, Moyer, BD, Hevezi, P, Lu, M, Kalabat, D, Zlotnik, A, Echeverri, F, Laita, B, Gao, N

BMC Neurosci 2009
Participants
Output
Catalyst Activity

sodium channel activity of Scn9a:Scn1b,2b,4b [plasma membrane]

Orthologous Events
Authored
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