Gnat3 exchanges GDP for GTP in Gnat3:Gnb1:Gng13

Stable Identifier
R-MMU-9724864
Type
Reaction
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Gnat3 exchanges GDP for GTP in Gnat3:Gnb1:Gng13

The binding of ligand to the umami receptor (Tas1r1:Tas1r3) or sweet receptor (Tas1r2:Tas1r3) causes a conformational change in the receptor that is transmitted to the associated gustducin G-protein heterotrimer (Gnat33:Gnb1,3:Gng13) and causes the alpha subunit, Gnat3 (gustducin), to exchange GDP for GTP (Wong et al. 1996). Gustducin alpha (Gnat3) and Ggamma 13 (Gng13) colocalize with Tas1r1:Tas1r3 bitter receptors and are required to activate downstream IP3 signaling (Huang et al. 1999, Caicedo et al. 2003). Loss of Gnat3 function causes loss of responsiveness to sweet tastants (Ruiz-Avila et al. 2001) and bitter tastants (Caicedo et al. 2003).

Literature References
PubMed ID Title Journal Year
8657284 Transduction of bitter and sweet taste by gustducin

Margolskee, RF, Gannon, KS, Wong, GT

Nature 1996
11447270 Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in alpha -gustducin

Margolskee, RF, Damak, S, Wong, GT, Ruiz-Avila, L

Proc Natl Acad Sci U S A 2001
14586025 Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli

Pereira, E, Margolskee, RF, Caicedo, A, Roper, SD

J. Neurosci. 2003
10570481 Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium

Shanker, YG, Margolskee, RF, Yan, W, Zheng, JZ, Spielman, AI, Rosenzweig, S, Max, M, Huang, L, Dubauskaite, J

Nat Neurosci 1999
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