Eomes, Wdr5, Kat2a, Tbxt bind the Mesp1 gene

Stable Identifier
R-MMU-9733738
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
3/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Eomes, Wdr5, Kat2a, Tbxt bind the Mesp1 gene
Mesodermal proteins Eomes (Costello et al. 2011, van den Ameele et al. 2012, Guo et al. 2018) and Tbxt (T, Brachyury) (David et al. 2011) bind the Mesp1 gene and activate transcription of Mesp1. Eomes and the non-coding RNA lincr1405 are in a complex containing the histone acetyltransferase Kat2a (Gcn5) and the histone-binding protein Wdr5 to activate transcription of Mesp1 (inferred from mouse homologs). (Wdr5 is a component of trithorax group/MLL histone acetyltransferase complexes therefore a MLL complex may bind the Mesp1 gene but this has not yet been demonstrated.) Tbxt binds a 3.4 kb region of the proximal promoter upstream of the first exon (David et al. 2011). Eomes mainly binds a T-box element 3.8 kb upstream of the first exon (van den Ameele et al. 2012). Mesp1 is the first observed marker of cardiac progenitor cells within the lateral plate mesoderm.
Literature References
PubMed ID Title Journal Year
21822279 The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation

Bikoff, EK, Costello, I, Pimeisl, IM, Dräger, S, Arnold, SJ, Robertson, EJ

Nat Cell Biol 2011
21632880 Induction of MesP1 by Brachyury(T) generates the common multipotent cardiovascular stem cell

Franz, WM, Lickert, H, Gegg, M, Jarsch, VB, David, R, Nathan, P, Schwarz, F

Cardiovasc Res 2011
29754779 A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis

Jia, W, Wu, Y, Lu, C, Zhu, S, Wang, Z, Guo, X, Liu, Z, Jiapaer, Z, Wang, G, Wan, X, Chen, J, Xu, Y, Xi, J, Kang, J, Gao, S

Cell Stem Cell 2018
22402664 Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin

Paulissen, C, Blanpain, C, Iacovino, M, Herpoel, A, Tiberi, L, Vanderhaeghen, P, Kyba, M, van den Ameele, J, Bondue, A

EMBO Rep. 2012
Participants
Input
Output
Orthologous Events
EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene (Homo sapiens)
Authored
May, B  (2021-06-07)
Created
May, B  (2021-06-10)
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