Reactome | Expression of Gsc in the primitive streak

Expression of Gsc in the primitive streak

Stable Identifier

R-MMU-9756950

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Expression of Gsc in the primitive streak

The Goosecoid (Gsc) gene is transcribed to yield mRNA and the mRNA is translated to yield Gsc protein. Expression of Gsc is first observed in the region of the epiblast where the primitive streak forms (Blum et al. 1992). Expression then becomes restricted to the anterior primitive streak and the anterior midline mesoderm. Phosphorylated Smad2 and Smad3 in complexes with Smad4 and Trim33 activate transcription of Gsc (Xi et al. 2011, Aragon et al. 2019).

Literature References

PubMed ID	Title	Journal	Year
1352187	Gastrulation in the mouse: the role of the homeobox gene goosecoid Blumberg, B, Steinbeisser, H, De Robertis, EM, Gaunt, SJ, Blum, M, Cho, KW, Bittner, D	Cell	1992
31582430	Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling Tian, L, Macias, MJ, Hu, J, Zou, Y, Shu, W, Massagué, J, Aragón, E, Wang, Q, Hadjantonakis, AK, Su, J, Gomes, T, Agrawal, S, Kaczmarska, Z, Torner, C, Márquez, JA, Ruiz, L, Morgani, SM	Genes Dev	2019
22196728	A poised chromatin platform for TGF-β access to master regulators Liu, JX, Zaromytidou, AI, Chow-Tsang, LF, Mark, W, Kaartinen, V, Barlas, A, Massagué, J, Manova-Todorova, K, Wang, Z, Studer, L, Zhang, XH, Xi, Q, Patel, DJ, Kim, H	Cell	2011