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Nfe2l2 [cytosol]
Stable Identifier
R-MMU-9758077
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
ub-NFE2L2, Q60795
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
KEAP1-NFE2L2 pathway (Mus musculus)
26S proteasome degrades Ub-NFE2L2 (Mus musculus)
Nfe2l2 [cytosol] (Mus musculus)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Mus musculus)
Nfe2l2 [cytosol] (Mus musculus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Mus musculus)
Nfe2l2 [cytosol] (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Mus musculus)
Nfe2l2 [cytosol] (Mus musculus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Mus musculus)
Nfe2l2 [cytosol] (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Mus musculus)
Nfe2l2 [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Neddylation (Mus musculus)
26S proteasome degrades Ub-NFE2L2 (Mus musculus)
Nfe2l2 [cytosol] (Mus musculus)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Mus musculus)
Nfe2l2 [cytosol] (Mus musculus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Mus musculus)
Nfe2l2 [cytosol] (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Mus musculus)
Nfe2l2 [cytosol] (Mus musculus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Mus musculus)
Nfe2l2 [cytosol] (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Mus musculus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Mus musculus)
Nfe2l2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q60795 Nfe2l2
Gene Names
Nfe2l2, Nrf2
Chain
chain:1-597
Reference Genes
BioGPS Gene:18024 Nfe2l2
ENSEMBL:ENSMUSG00000015839.7 Nfe2l2
KEGG Gene (Mus musculus):18024 Nfe2l2
Monarch:18024 Nfe2l2
NCBI Gene:18024 Nfe2l2
UCSC:Q60795 Nfe2l2
Reference Transcript
RefSeq:NM_010902.4 Nfe2l2
Other Identifiers
10483809
1416543_at
17386700
18024
4535255
4536767
4844970
5035745
5062339
5115171
5264160
92562_at
A_51_P411271
A_52_P396436
GE35797
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001221
GO:0001228
GO:0002376
GO:0002931
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0006575
GO:0006790
GO:0006954
GO:0006979
GO:0008134
GO:0009410
GO:0010033
GO:0010468
GO:0010499
GO:0010628
GO:0010667
GO:0010976
GO:0012501
GO:0016567
GO:0019904
GO:0023052
GO:0030154
GO:0030163
GO:0030194
GO:0030968
GO:0031625
GO:0032993
GO:0034599
GO:0034976
GO:0036211
GO:0036499
GO:0042060
GO:0042149
GO:0043161
GO:0043226
GO:0043536
GO:0043565
GO:0045088
GO:0045454
GO:0045766
GO:0045893
GO:0045944
GO:0045995
GO:0046223
GO:0046326
GO:0048856
GO:0048870
GO:0051171
GO:0055085
GO:0061629
GO:0070301
GO:0071280
GO:0071356
GO:0071456
GO:0071466
GO:0071498
GO:0071499
GO:0080090
GO:0090575
GO:0098542
GO:0098754
GO:0140110
GO:1900038
GO:1900407
GO:1902037
GO:1902176
GO:1903788
GO:1904385
GO:1904753
GO:2000121
GO:2000352
GO:2000379
ILMN_1214369
ILMN_1224128
mMC006301
u70475_s_at
Participates
as an input of
26S proteasome degrades Ub-NFE2L2 (Mus musculus)
as an output of
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Mus musculus)
as a component of
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Mus musculus)
Other forms of this molecule
p-S,T-Nfe2l2 [cytoplasm]
phospho-Nfe2l2 [nucleoplasm]
phospho-Nfe2l2 [nucleoplasm]
phospho-Nfe2l2 [nucleoplasm]
phospho-Nfe2l2 [nucleoplasm]
phospho-Nfe2l2 [nucleoplasm]
Nfe2l2 [nucleoplasm]
phospho-Nfe2l2 [nucleoplasm]
phospho-Nfe2l2 [nucleoplasm]
phospho-Nfe2l2 [cytosol]
phospho-Nfe2l2 [cytosol]
Nfe2l2 [cytosol]
Nfe2l2 [cytosol]
p-Nfe2l2 [cytosol]
phospho-Nfe2l2 [nucleoplasm]
phospho-Nfe2l2 [nucleoplasm]
Inferred From
ub-NFE2L2 [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K48-linked polyubiquitin chain [cytosol]) at unknown position
Modification
K48-linked polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_035032.1
Ensembl
ENSMUSG00000015839
,
ENSMUST00000102672
,
ENSMUSP00000099733
PRO
Q60795
MGI
108420
PDB
3WN7
,
1X2R
,
2DYH
,
7ECA
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Z2X8
3
Keap1 [cytosol]
(R-MMU-6782766)
Keap1 [cytosol]
(R-MMU-9766647)
Keap1 [cytosol]
(R-MMU-976038)
0.819
25
UniProt:P97474 PITX2
0.524
2
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