Reactome | Gan [cytosol]

Gan [cytosol]

Stable Identifier

R-MMU-976014

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

GAN, Q8CA72

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Mus musculus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8CA72

Gene Names

Gan

Reference Genes

BioGPS Gene:209239 Gan

ENSEMBL:ENSMUSG00000052557

ENSEMBL:ENSMUSG00000052557.12 Gan

KEGG Gene (Mus musculus):209239 Gan

Monarch:209239 Gan

NCBI Gene:209239 Gan

UCSC:Q8CA72 Gan

Reference Transcript

RefSeq:NM_001081151.1 Gan

Other Identifiers

10575763

1439615_at

17505953

209239

4317916

4462011

4774527

4819839

4895856

4935054

4967301

5051557

5070530

5438324

5476371

5493345

A_51_P125986

GE1493554

GO:0005515

GO:0005737

GO:0005856

GO:0007010

GO:0016567

GO:0031463

GO:0036211

GO:0043226

ILMN_1218451

ILMN_1228488

ILMN_3091801

mMC015178

Participates

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Mus musculus)

as a member of

BTB proteins [cytosol] (Mus musculus)

Inferred From

GAN [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001074620.1

Ensembl

ENSMUST00000064488, ENSMUSG00000052557, ENSMUSP00000070168

PRO

Q8CA72

MGI

1890619

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