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RBCK1 [cytosol]
Stable Identifier
R-MMU-976018
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q9WUB0
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Class I MHC mediated antigen processing & presentation (Mus musculus)
Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
Polyubiquitination of substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
Release of E3 from polyubiquitinated substrate (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
E3:Ub:substrate [cytosol] (Mus musculus)
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Mus musculus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
LUBAC ubiquitinates RIPK1 at K627 (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
OPTN recruits CYLD to the TNFR1 complex (Mus musculus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNFR1-induced NF-kappa-B signaling pathway (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:CHUK:IKBKB:IKBKG [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIP1:LUBAC:BIRC2/3:TAB1:TAK1:TAB2/3 [plasma membrane] (Mus musculus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
TNFR1-induced proapoptotic signaling (Mus musculus)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Mus musculus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Mus musculus)
CYLD:SPATA2:LUBAC [cytosol] (Mus musculus)
LUBAC [cytosol] (Mus musculus)
RBCK1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9WUB0
Reference Genes
BioGPS Gene:24105
ENSEMBL:ENSMUSG00000027466
ENSEMBL:ENSMUSG00000027466.16
Monarch:24105
NCBI Gene:24105
UCSC:Q9WUB0
Reference Transcript
RefSeq:NM_019705.3
RefSeq:NM_001083921.1
Other Identifiers
10488594
1415792_at
17392906
24105
4438841
4844103
4852952
4933583
4943521
4971501
4976797
5052904
5074975
5149634
5293892
5334789
5336610
5344873
5506068
5531649
5600333
94457_at
A_51_P233578
A_55_P2039105
GE37621
GO:0000209
GO:0002376
GO:0003677
GO:0003690
GO:0003713
GO:0003824
GO:0004842
GO:0005080
GO:0005515
GO:0006351
GO:0006355
GO:0012501
GO:0016567
GO:0016740
GO:0023052
GO:0030163
GO:0036211
GO:0042742
GO:0042802
GO:0043065
GO:0043123
GO:0043130
GO:0043161
GO:0045944
GO:0046872
GO:0050852
GO:0051220
GO:0060546
GO:0071797
GO:0097039
GO:0098542
GO:0140096
GO:0140110
GO:0140311
GO:0140313
GO:1901224
GO:2001238
ILMN_1214070
mMC016600
w49397_at
w49397_g_at
Participates
as a component of
LUBAC [cytosol] (Mus musculus)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
Inferred From
RBCK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_062679.2
,
NP_001077390.1
Ensembl
ENSMUST00000109847
,
ENSMUSP00000028964
,
ENSMUSP00000105473
,
ENSMUST00000028964
,
ENSMUSG00000027466
PRO
Q9WUB0
MGI
1344372
PDB
3B0A
,
5Y3T
,
8IM5
,
3B08
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P97767 Eya1
3
Eya1 [nucleoplasm]
(R-MMU-9830959)
EYA1 [nucleoplasm]
(R-MMU-5683625)
phospho-p-EYA1 [nucleoplasm]
(R-MMU-5683951)
0.524
2
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