Reactome | Lrr1 [cytosol]

Lrr1 [cytosol]

Stable Identifier

R-MMU-976019

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

LRR1, D3YY91

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Lrr1 [cytosol] (Mus musculus)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Lrr1 [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Lrr1 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Lrr1 [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Lrr1 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Lrr1 [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Lrr1 [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Lrr1 [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Mus musculus)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Lrr1 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL2-box protein [cytosol] (Mus musculus)
        
        Lrr1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:D3YY91

Gene Names

Lrr1

Reference Genes

BioGPS Gene:69706 Lrr1

ENSEMBL:ENSMUSG00000034883

ENSEMBL:ENSMUSG00000034883.10 Lrr1

KEGG Gene (Mus musculus):69706 Lrr1

Monarch:69706 Lrr1

NCBI Gene:69706 Lrr1

UCSC:D3YY91 Lrr1

Reference Transcript

RefSeq:NM_001081406.1 Lrr1

Other Identifiers

10396068

1427506_at

1436922_at

1452458_s_at

17275875

4780695

5128479

5196870

5264271

5505258

69706

A_51_P347240

A_55_P2076941

GO:0003674

GO:0005515

GO:0005634

GO:0007165

GO:0016567

GO:0023052

GO:0036211

GO:0043226

ILMN_1212884

mMC016426

Participates

as a member of

CUL2-box protein [cytosol] (Mus musculus)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Mus musculus)

Inferred From

LRR1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001074875.1

Ensembl

ENSMUSP00000106251, ENSMUSG00000034883, ENSMUST00000110621

MGI

1916956

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