Reactome | Keap1 [cytosol]

Keap1 [cytosol]

Stable Identifier

R-MMU-976038

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

KEAP1, Q9Z2X8

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Keap1 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Keap1 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Keap1 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Keap1 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Keap1 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Keap1 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Keap1 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Keap1 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Keap1 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Keap1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9Z2X8

Gene Names

Keap1

Reference Genes

BioGPS Gene:50868 Keap1

ENSEMBL:ENSMUSG00000003308

ENSEMBL:ENSMUSG00000003308.16 Keap1

KEGG Gene (Mus musculus):50868 Keap1

Monarch:50868 Keap1

NCBI Gene:50868 Keap1

UCSC:Q9Z2X8 Keap1

Reference Transcript

Other Identifiers

10591482

1450746_at

1450747_at

17524659

4308634

4450046

4547708

4705568

4772799

4919759

5045304

50868

5238700

5430939

5454466

5552467

A_51_P438666

GE36980

GO:0001701

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005815

GO:0005829

GO:0005856

GO:0005884

GO:0005912

GO:0005925

GO:0006351

GO:0006355

GO:0006511

GO:0006914

GO:0008152

GO:0010506

GO:0010629

GO:0016234

GO:0016567

GO:0030154

GO:0030163

GO:0030496

GO:0031463

GO:0032991

GO:0034451

GO:0034599

GO:0036211

GO:0042802

GO:0043226

GO:0045604

GO:0048856

GO:0060090

GO:0061629

GO:0070887

GO:0071322

GO:0071353

GO:0097718

GO:1990756

ILMN_1258406

ILMN_2442976

ILMN_2621346

ILMN_2707771

ILMN_2993267

mMC006958

Participates

as a member of

as a component of

KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Mus musculus)

Other forms of this molecule

Keap1 [cytosol]

Inferred From

KEAP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001103776.1, NP_001103777.1, NP_001103775.1, NP_057888.1

Ensembl

ENSMUSP00000062467, ENSMUSP00000141807, ENSMUST00000164812, ENSMUSP00000131029, ENSMUST00000194542, ENSMUSP00000141840, ENSMUST00000049567, ENSMUST00000193982, ENSMUSG00000003308

PRO

Q9Z2X8

MGI

1858732

PDB

1X2J, 6ZEW, 7OFF, 7OF8, 8IN0, 4ZY3, 6ZF4, 7OFE, 5FNU, 1X2R, 6ZF5, 6QME, 6ZEX, 6QMJ, 6ZF0, 7OF9, 5FZJ, 7OFB, 5FNQ, 7OFA, 5FNR, 8A46, 3WDZ, 6ZEZ, 7ECA, 7P5P, 5CGJ, 7OFD, 7P58, 7C60, 3WN7, 7OFC, 6QMC, 7P5F, 7P5E, 8Q1R, 7P5K, 2DYH, 7P5I, 6ZEY, 6ZF6, 6ZF7, 6QMD, 7P5N, 7C5E, 6ZF2, 6QMK, 6ZF1, 6ZF8, 8Q1Q, 5FZN, 3ADE, 6ZF3, 7YEN, 2Z32, 5FNS, 5FNT

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q60795 Nfe2l2	17	p-S,T-Nfe2l2 [cytoplasm] (R-MMU-9818709) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9795736) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9762050) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9762048) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9762058) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9762055) Nfe2l2 [cytosol] (R-MMU-9758077) Nfe2l2 [nucleoplasm] (R-MMU-9759078) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9715109) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9715110) phospho-Nfe2l2 [cytosol] (R-MMU-8932290) phospho-Nfe2l2 [cytosol] (R-MMU-8932311) Nfe2l2 [cytosol] (R-MMU-201566) Nfe2l2 [cytosol] (R-MMU-8932335) p-Nfe2l2 [cytosol] (R-MMU-8932371) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9760033) phospho-Nfe2l2 [nucleoplasm] (R-MMU-9760018)	0.819	25
UniProt:Q64337	5	K7 ub-SQSTM1 [cytosol] (R-MMU-9759088) phospho-p-S349 SQSTM1 [cytosol] (R-MMU-9766524) phospho-ub K420 p-S349 SQSTM1 [cytosol] (R-MMU-9766536) SQSTM1 [nucleoplasm] (R-MMU-210961) SQSTM1 [cytosol] (R-MMU-193937)	0.65	6

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