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Xpo1 [nucleoplasm]
Stable Identifier
R-MMU-9769779
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
Exportin-1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
Mitotic G2-G2/M phases (Mus musculus)
G2/M Transition (Mus musculus)
Cyclin A/B1/B2 associated events during G2/M transition (Mus musculus)
Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Heme signaling (Mus musculus)
XPO1 (CRM1) binds to BACH1:Hemes (Mus musculus)
XPO1:BACH1:Hemes [nucleoplasm] (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
XPO1:BACH1:Hemes are transported out of the nucleus (Mus musculus)
XPO1:BACH1:Hemes [nucleoplasm] (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
Developmental Biology (Mus musculus)
MITF-M-regulated melanocyte development (Mus musculus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Mus musculus)
XPO1 binds p-S69,73 MITF-M (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
p-S69,73 MITF-M:XPO1 [nucleoplasm] (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
XPO1-dependent export of p-S69,S73 MITF-M (Mus musculus)
p-S69,73 MITF-M:XPO1 [nucleoplasm] (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
Metabolism of RNA (Mus musculus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Mus musculus)
HuR (ELAVL1) binds and stabilizes mRNA (Mus musculus)
HuR binds the CRM1 nuclear export machinery (Mus musculus)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
HuR:mRNA complex translocates from the nucleus to the cytosol (Mus musculus)
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK6/MAPK4 signaling (Mus musculus)
MAPK4,6 translocate to the cytoplasm (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Mus musculus)
p-S10 CDKN1B translocates to the cytosol (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
Signaling by WNT (Mus musculus)
TCF dependent signaling in response to WNT (Mus musculus)
Deactivation of the beta-catenin transactivating complex (Mus musculus)
XPO1 binds the beta-catenin:CBY complex (Mus musculus)
XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [nucleoplasm] (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
YWHAZ and XPO1 mediate the nuclear export of beta-catenin (Mus musculus)
XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [nucleoplasm] (Mus musculus)
Xpo1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q6P5F9 Xpo1
Gene Names
Xpo1, Crm1
Chain
chain:1-1071
Reference Genes
BioGPS Gene:103573 Xpo1
KEGG:mmu:103573 Xpo1
Monarch:103573 Xpo1
NCBI Gene:103573 Xpo1
UCSC:Q6P5F9 Xpo1
Reference Transcript
RefSeq:NM_134014.3 Xpo1
RefSeq:XM_006514430.2 Xpo1
RefSeq:NM_001035226.1 Xpo1
Other Identifiers
103573
10374590
1418442_at
1418443_at
1448070_at
17247695
4390438
4435797
4452783
4591119
4597725
4610899
4617081
4639105
4729603
4742940
4798573
4800305
4830684
4862183
4935227
4940576
4940931
4979940
4985790
5027282
5065885
5120875
5135169
5258162
5264477
5276209
5283282
5351774
5422937
5436157
5436749
5454853
5501504
5508842
5510025
5513272
5541295
5545484
5565613
5584169
5610418
94131_at
94228_at
AA154817_at
A_51_P336635
A_52_P633543
A_55_P2089942
GE127911
GO:0000054
GO:0000055
GO:0000056
GO:0000122
GO:0000776
GO:0003723
GO:0005049
GO:0005515
GO:0005634
GO:0005642
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006355
GO:0006406
GO:0006611
GO:0006886
GO:0006913
GO:0010824
GO:0015030
GO:0015031
GO:0019904
GO:0031267
GO:0031965
GO:0032434
GO:0032991
GO:0034504
GO:0042176
GO:0042254
GO:0043226
GO:0043231
GO:0046825
GO:0051028
GO:0140104
GO:0140297
GO:1990904
ILMN_2481528
ILMN_2490008
ILMN_3123321
aa267296_s_at
aa545124_at
aa545124_g_at
mMC006183
mMR028377
Participates
as an input of
HuR binds the CRM1 nuclear export machinery (Mus musculus)
XPO1 binds p-S69,73 MITF-M (Mus musculus)
XPO1 (CRM1) binds to BACH1:Hemes (Mus musculus)
XPO1 binds the beta-catenin:CBY complex (Mus musculus)
as a component of
HuR:APRIL:pp32:SET(SETalpha):Nup214(SETbeta):CRM1 [nucleoplasm] (Mus musculus)
p-S69,73 MITF-M:XPO1 [nucleoplasm] (Mus musculus)
XPO1:BACH1:Hemes [nucleoplasm] (Mus musculus)
XPO1:YWHAZ:p-S20-CBY1:CTNNB1 [nucleoplasm] (Mus musculus)
This entity regulates
Positively
MAPK4,6 translocate to the cytoplasm
(Mus musculus)
Npas4 translocates to the cytosol
(Rattus norvegicus)
p-S10 CDKN1B translocates to the cytosol
(Mus musculus)
Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm
(Mus musculus)
Other forms of this molecule
Xpo1 [cytosol]
Inferred From
XPO1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_001030303.1
,
NP_598775.2
,
XP_006514493.1
ENSEMBL
ENSMUST00000102870
,
ENSMUSP00000099934
,
ENSMUSP00000099933
,
ENSMUST00000102869
PRO
Q6P5F9
GlyGen
Q6P5F9
MGI
2144013
PDB
3NBZ
,
3NC0
,
3NC1
,
3GJX
,
3NBY
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62826 RAN
2
RAN [cytosol]
(R-HSA-165540)
RAN [nucleoplasm]
(R-HSA-165528)
0.676
3
UniProt:P61925 IPKA
0.645
4
UniProt:O95149 SNUPN
1
SNUPN [cytosol]
(R-HSA-191857)
0.59
2
UniProt:Q13523 PRPF4B
1
PRPF4B [nucleoplasm]
(R-HSA-9769525)
0.527
2
UniProt:Q6GNU1 AR1BB
0.525
2
UniProt:B7ZR20 B7ZR20
0.525
2
UniProt:Q91855 Q91855
0.525
2
UniProt:Q3B8L5 Q3B8L5
0.525
2
UniProt:Q00987 MDM2
11
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
MDM2 [cytosol]
(R-HSA-198644)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
MDM2 [plasma membrane]
(R-HSA-416843)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
0.499
4
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