Reactome | Fos [nucleoplasm]

Fos [nucleoplasm]

Stable Identifier

R-MMU-9769935

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Proto-oncogene c-Fos

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-17 signaling (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        Activation of the AP-1 family of transcription factors (Mus musculus)
        
        c-FOS activation by phospho ERK1/2 (Mus musculus)
        
        Fos [nucleoplasm] (Mus musculus)
- Innate Immune System (Mus musculus)
  - Fc epsilon receptor (FCERI) signaling (Mus musculus)
    - FCERI mediated MAPK activation (Mus musculus)
      - c-FOS activation by phospho ERK1/2 (Mus musculus)
        
        Fos [nucleoplasm] (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        Activation of the AP-1 family of transcription factors (Mus musculus)
        
        c-FOS activation by phospho ERK1/2 (Mus musculus)
        
        Fos [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        Activation of the AP-1 family of transcription factors (Mus musculus)
        
        c-FOS activation by phospho ERK1/2 (Mus musculus)
        
        Fos [nucleoplasm] (Mus musculus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        Activation of the AP-1 family of transcription factors (Mus musculus)
        
        c-FOS activation by phospho ERK1/2 (Mus musculus)
        
        Fos [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
      - MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        Activation of the AP-1 family of transcription factors (Mus musculus)
        
        c-FOS activation by phospho ERK1/2 (Mus musculus)
        
        Fos [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        Activation of the AP-1 family of transcription factors (Mus musculus)
        
        c-FOS activation by phospho ERK1/2 (Mus musculus)
        
        Fos [nucleoplasm] (Mus musculus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        Activation of the AP-1 family of transcription factors (Mus musculus)
        
        c-FOS activation by phospho ERK1/2 (Mus musculus)
        
        Fos [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        Activation of the AP-1 family of transcription factors (Mus musculus)
        
        c-FOS activation by phospho ERK1/2 (Mus musculus)
        
        Fos [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        Activation of the AP-1 family of transcription factors (Mus musculus)
        
        c-FOS activation by phospho ERK1/2 (Mus musculus)
        
        Fos [nucleoplasm] (Mus musculus)
    - Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        MAP kinase activation (Mus musculus)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Mus musculus)
        
        Activation of the AP-1 family of transcription factors (Mus musculus)
        
        c-FOS activation by phospho ERK1/2 (Mus musculus)
        
        Fos [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P01101 Fos

Gene Names

Fos

Chain

chain:1-380

Reference Genes

BioGPS Gene:14281 Fos

ENSEMBL:ENSMUSG00000021250.14 Fos

KEGG Gene (Mus musculus):14281 Fos

Monarch:14281 Fos

NCBI Gene:14281 Fos

UCSC:P01101 Fos

Reference Transcript

RefSeq:NM_010234.2 Fos

Other Identifiers

10397346

1423100_at

14281

160901_at

17277387

4392129

4482940

4817672

5023048

5090870

5126137

5143783

A_52_P262219

A_55_P2910184

GE35420

GO:0000976

GO:0000978

GO:0000979

GO:0000981

GO:0001221

GO:0001228

GO:0001661

GO:0002376

GO:0003677

GO:0003682

GO:0003690

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005783

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0007179

GO:0007399

GO:0007565

GO:0009410

GO:0009416

GO:0009612

GO:0009629

GO:0009636

GO:0010468

GO:0014070

GO:0014823

GO:0014856

GO:0022414

GO:0023052

GO:0030154

GO:0030316

GO:0031668

GO:0032496

GO:0032570

GO:0032868

GO:0032870

GO:0032993

GO:0034097

GO:0034224

GO:0034614

GO:0035902

GO:0035914

GO:0035976

GO:0035994

GO:0042802

GO:0043226

GO:0043565

GO:0044877

GO:0045471

GO:0045672

GO:0045893

GO:0045944

GO:0048545

GO:0048856

GO:0050877

GO:0051412

GO:0051450

GO:0051591

GO:0060395

GO:0061629

GO:0070412

GO:0071276

GO:0071277

GO:0071356

GO:0071364

GO:0071374

GO:0071456

GO:0071560

GO:0090575

GO:0140110

GO:1902895

GO:1903131

GO:1904628

GO:1990646

GO:1990837

ILMN_2750515

mMC013536

v00727_s_at

Participates

as an output of

Npas4 stimulates Fos gene transcription (Mus musculus)

as an input of

c-FOS activation by phospho ERK1/2 (Mus musculus)

Other forms of this molecule

phospho-Fos [nucleoplasm]

Inferred From

FOS [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_034364.1

Ensembl

ENSMUSG00000021250, ENSMUSP00000021674, ENSMUST00000021674

PRO

P01101

MGI

95574

PDB

2WT7

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54841 Mafb	1	Mafb [nucleoplasm] (R-MMU-3788650)	0.645	4
UniProt:O08537	5	Esr2 [cytosol] (R-MMU-9020979) Esr2 [plasma membrane] (R-MMU-9021059) Esr2 [plasma membrane] (R-MMU-9637787) Esr2 [nucleoplasm] (R-MMU-446165) Esr2 [cytosol] (R-MMU-9020970)	0.524	2
UniProt:P14404 Mecom	1	Mecom [nucleoplasm] (R-MMU-9830485)	0.499	2

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