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Eif4e [cytosol]
Stable Identifier
R-MMU-9817689
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
fullName evidence="13"Eukaryotic translation initiation factor 4E, IF4E_MOUSE
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Interferon Signaling (Mus musculus)
Antiviral mechanism by IFN-stimulated genes (Mus musculus)
ISG15 antiviral mechanism (Mus musculus)
Competitive inhibition of translation initiation by ISGylated 4EHP (Mus musculus)
EIF4F [cytosol] (Mus musculus)
EIF4E1/EIF4E3 [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
eIF4F:mRNA [cytosol] (Mus musculus)
EIF4F [cytosol] (Mus musculus)
EIF4E1/EIF4E3 [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Metabolism of RNA (Mus musculus)
Deadenylation-dependent mRNA decay (Mus musculus)
Deadenylation of mRNA (Mus musculus)
CCR4-NOT complex deadenylates mRNA (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Partially Deadenylated mRNA Complex [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
PAN2-PAN3 complex partially deadenylates mRNA (Mus musculus)
Partially Deadenylated mRNA Complex [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Translatable mRNA Complex [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
PARN deadenylates mRNA (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Partially Deadenylated mRNA Complex [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Processing of Capped Intron-Containing Pre-mRNA (Mus musculus)
Transport of Mature Transcript to Cytoplasm (Mus musculus)
Transport of Mature mRNAs Derived from Intronless Transcripts (Mus musculus)
Transport of Mature mRNA Derived from an Intronless Transcript (Mus musculus)
Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Mature Intronless Transcript Derived mRNA:eIF4E Complex [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Transport of the SLBP Dependant Mature mRNA (Mus musculus)
Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Transport of the SLBP independent Mature mRNA (Mus musculus)
Release of the SLBP independent Histone mRNA from the NPC (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Mature SLBP independent Histone mRNA:eIF4E complex [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Metabolism of proteins (Mus musculus)
Translation (Mus musculus)
Eukaryotic Translation Initiation (Mus musculus)
Cap-dependent Translation Initiation (Mus musculus)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Mus musculus)
Cap-bound mRNA is activated by helicases (Mus musculus)
eIF4F:mRNP [cytosol] (Mus musculus)
eIF4F [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Mus musculus)
eIF4F [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Formation of the cap-binding eIF4F complex (Mus musculus)
Eif4e [cytosol] (Mus musculus)
eIF4F [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Release of eIF4E from the inactive eIF4E:4E-BP complex (Mus musculus)
Eif4e [cytosol] (Mus musculus)
eIF4E:4E-BP [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Translation initiation complex formation (Mus musculus)
Formation of translation initiation complexes containing mRNA that does not circularize (Mus musculus)
48S complex [cytosol] (Mus musculus)
eIF4F [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Mus musculus)
eIF4F [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Mus musculus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
eIF4F [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Mus musculus)
eIF4F [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
GTP hydrolysis and joining of the 60S ribosomal subunit (Mus musculus)
eIF2:GTP is hydrolyzed, eIFs are released (Mus musculus)
48S complex [cytosol] (Mus musculus)
eIF4F [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Ribosomal scanning and start codon recognition (Mus musculus)
Ribosomal scanning (Mus musculus)
48S complex [cytosol] (Mus musculus)
eIF4F [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Start codon recognition (Mus musculus)
48S complex [cytosol] (Mus musculus)
eIF4F [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
L13a-mediated translational silencing of Ceruloplasmin expression (Mus musculus)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Mus musculus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
eIF4F [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Mus musculus)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Mus musculus)
eIF4F [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
MTOR signalling (Mus musculus)
mTORC1-mediated signalling (Mus musculus)
Dissociation of phosphorylated 4EBP1 from eIF4E (Mus musculus)
Eif4e [cytosol] (Mus musculus)
eIF4E:4E-BP1-P [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
Phosphorylation of 4E-BP1 by activated mTORC1 (Mus musculus)
eIF4E:4E-BP [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
eIF4E:4E-BP1-P [cytosol] (Mus musculus)
Eif4e [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P63073 Eif4e
Gene Names
Eif4e
Chain
initiator methionine:, chain:2-217
Reference Genes
BioGPS Gene:13684 Eif4e
KEGG:mmu:13684 Eif4e
Monarch:13684 Eif4e
NCBI Gene:13684 Eif4e
UCSC:P63073 Eif4e
Reference Transcript
RefSeq:XM_036162887.1 Eif4e
RefSeq:NM_007917.4 Eif4e
Other Identifiers
10496485
10496490
10599855
13684
1423220_at
1444010_at
1450908_at
1450909_at
17403138
17403148
4585511
4596592
4670189
4777405
4820601
4837845
4838945
4842499
4912793
4924058
4927240
5138832
5187848
5220386
5233889
5305673
5367728
5394598
5480520
5497109
5500869
5517686
5539009
5549752
5576508
5589014
99097_at
A_51_P131895
A_52_P310981
A_52_P671013
A_55_P1965584
A_55_P1972422
A_55_P1974533
A_55_P1974538
GE1434572
GE1451202
GE42487
GO:0000082
GO:0000340
GO:0000932
GO:0001662
GO:0003723
GO:0003743
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006406
GO:0006412
GO:0006413
GO:0006417
GO:0006913
GO:0010494
GO:0016281
GO:0016442
GO:0016604
GO:0016607
GO:0017148
GO:0019827
GO:0019899
GO:0030154
GO:0030182
GO:0031370
GO:0033391
GO:0036464
GO:0043226
GO:0045182
GO:0045665
GO:0045931
GO:0048471
GO:0051028
GO:0051168
GO:0071549
GO:0098794
GO:0098808
GO:0098978
GO:0099578
GO:0140297
ILMN_1241672
ILMN_1260038
ILMN_2669551
ILMN_2777405
M61731_s_at
mMC005612
mMC020207
mMC025802
Participates
as a component of
deadenylated mRNP regulated by Btg4 [cytosol] (Mus musculus)
mRNP regulated by Btg4 [cytosol] (Mus musculus)
Uridylated partially deadenylated mRNA complex [cytosol] (Mus musculus)
Partially deadenylated mRNA complex [cytosol] (Mus musculus)
Partially Deadenylated mRNA Complex [cytosol] (Mus musculus)
Translatable mRNA Complex [cytosol] (Mus musculus)
Mature Intronless Transcript Derived mRNA:eIF4E Complex [cytosol] (Mus musculus)
Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex [cytosol] (Mus musculus)
Mature SLBP independent Histone mRNA:eIF4E complex [cytosol] (Mus musculus)
eIF4F [cytosol] (Mus musculus)
eIF4E:4E-BP1-P [cytosol] (Mus musculus)
eIF4E:4E-BP [cytosol] (Mus musculus)
as an output of
CCR4-NOT complex deadenylates mRNA (Mus musculus)
PARN deadenylates mRNA (Mus musculus)
eIF2:GTP is hydrolyzed, eIFs are released (Mus musculus)
Release of eIF4E from the inactive eIF4E:4E-BP complex (Mus musculus)
Dissociation of phosphorylated 4EBP1 from eIF4E (Mus musculus)
as an input of
Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC (Mus musculus)
Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex (Mus musculus)
Release of the SLBP independent Histone mRNA from the NPC (Mus musculus)
Formation of the cap-binding eIF4F complex (Mus musculus)
as a member of
EIF4E1/EIF4E3 [cytosol] (Mus musculus)
Inferred From
EIF4E [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_036018780.1
,
NP_031943.3
ENSEMBL
ENSMUST00000029803
,
ENSMUSP00000029803
,
ENSMUSG00000028156
ZINC - Substances
IF4E_MOUSE
ZINC target
P63073
PRO
P63073
ZINC - Predictions - Purchasable
IF4E_MOUSE
MGI
95305
PDB
5M7V
,
1EJ4
,
5M7Z
,
5M7X
,
5M7W
,
5J5Y
,
5M80
,
5M81
,
1L8B
,
5BXV
,
6U09
,
6GKK
,
6YLR
,
6GKJ
,
6U06
,
1EJH
,
5M83
,
6GKL
,
6YLT
,
6YLV
,
5M84
,
1EJ1
,
5OSX
,
5J5O
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6NZJ6 Eif4g1
3
Eif4g1 [cytosol]
(R-MMU-9817630)
phospho-Eif4g1 [cytosol]
(R-MMU-165762)
Eif4g1 [cytosol]
(R-MMU-72584)
0.718
7
UniProt:Q60876
2
phospho-Eif4ebp1 [cytosol]
(R-MMU-165685)
Eif4ebp1 [cytosol]
(R-MMU-72580)
0.641
3
UniProt:Q7TMB8
5
Cyfip1 [tertiary granule lumen]
(R-MMU-6800176)
Cyfip1 [specific granule lumen]
(R-MMU-6800167)
Cyfip1 [extracellular region]
(R-MMU-6800473)
Cyfip1 [secretory granule lumen]
(R-MMU-6800940)
Cyfip1 [cytosol]
(R-MMU-5672575)
0.628
5
UniProt:Q7L576 CYFIP1
5
CYFIP1 [cytosol]
(R-HSA-5672575)
CYFIP1 [secretory granule lumen]
(R-HSA-6800940)
CYFIP1 [extracellular region]
(R-HSA-6800473)
CYFIP1 [specific granule lumen]
(R-HSA-6800167)
CYFIP1 [tertiary granule lumen]
(R-HSA-6800176)
0.525
2
UniProt:P62754 Rps6
4
Rps6 [nucleoplasm]
(R-MMU-6790606)
Rps6 [cytosol]
(R-MMU-9629876)
phospho-Rps6 [cytosol]
(R-MMU-165727)
Rps6 [cytosol]
(R-MMU-9633488)
0.499
2
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