Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
K48polyUb-K338, K530-CYLD [cytosol]
Stable Identifier
R-MMU-9818664
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q80TQ2
Locations in the PathwayBrowser for interactor UniProt:Q9Z2V5 Hdac6
Expand all
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
TNF signaling (Mus musculus)
Regulation of TNFR1 signaling (Mus musculus)
MIB2 ubiquitinates CYLD at K338, K530 (Mus musculus)
K48polyUb-K338, K530-CYLD [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q80TQ2
Reference Genes
BioGPS Gene:74256
ENSEMBL:ENSMUSG00000036712
KEGG:mmu:74256
Monarch:74256
NCBI Gene:74256
UCSC:Q80TQ2
Reference Transcript
RefSeq:XM_006531418.2
RefSeq:NM_001128171.2
RefSeq:XM_011248524.1
RefSeq:XM_006531414.1
RefSeq:NM_001128170.2
RefSeq:XM_006531416.3
RefSeq:NM_173369.3
RefSeq:XM_017312989.1
RefSeq:XM_006531415.1
RefSeq:XM_006531417.2
RefSeq:XM_011248523.2
RefSeq:XM_011248525.2
Other Identifiers
10573803
109511_at
1429201_at
1429617_at
1429618_at
1445213_at
162613_at
17503681
4304972
4305825
4352985
4375205
4503525
4528337
4530881
4547281
4586800
4589449
4615820
4623682
4630329
4632046
4719696
4770741
4774640
4836298
4838837
4847483
4933966
4989725
5234480
5248184
5424440
5435671
5436206
5455214
5461798
5511515
5538809
5550948
5572676
5617552
74256
A_51_P128267
A_51_P300001
A_51_P516097
A_52_P218976
A_55_P2015277
A_55_P2728257
GE39251
GO:0002376
GO:0003824
GO:0004843
GO:0005515
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0005881
GO:0005886
GO:0006355
GO:0006508
GO:0007346
GO:0008234
GO:0008270
GO:0009898
GO:0010803
GO:0012501
GO:0016055
GO:0016579
GO:0016787
GO:0019901
GO:0030496
GO:0032088
GO:0036064
GO:0042995
GO:0043226
GO:0043369
GO:0045087
GO:0045577
GO:0045582
GO:0046329
GO:0046872
GO:0048471
GO:0048872
GO:0050727
GO:0050728
GO:0050856
GO:0050862
GO:0060544
GO:0061578
GO:0065003
GO:0070064
GO:0070266
GO:0070507
GO:0070536
GO:0090090
GO:0097542
GO:0098542
GO:0140096
GO:1901026
GO:1901223
GO:1902017
GO:1903753
GO:1903829
GO:1990108
GO:1990380
GO:2000493
GO:2001238
GO:2001242
ILMN_1230581
ILMN_1233446
ILMN_1241707
ILMN_1249598
ILMN_1260381
ILMN_2416340
mMC003414
mMC011824
Participates
as an output of
MIB2 ubiquitinates CYLD at K338, K530 (Mus musculus)
Other forms of this molecule
CYLD [cytosol]
phospho-p-S418-CYLD [cytosol]
Inferred From
K48polyUb-K338, K530-CYLD [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 338 (in Homo sapiens)
Coordinate
338
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 530 (in Homo sapiens)
Coordinate
530
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_006531477.1
,
NP_001121642.1
,
XP_006531480.1
,
NP_775545.1
,
XP_011246827.1
,
XP_006531481.1
,
NP_001121643.1
,
XP_011246826.1
,
XP_006531478.1
,
XP_011246825.1
,
XP_017168478.1
,
XP_006531479.1
ENSEMBL
ENSMUST00000209559
,
ENSMUSP00000096119
,
ENSMUSP00000148037
,
ENSMUST00000109626
,
ENSMUSP00000147426
,
ENSMUST00000098519
,
ENSMUST00000209532
,
ENSMUSP00000147654
,
ENSMUST00000211554
,
ENSMUSP00000105254
IntEnz
3.4.19.12
PRO
Q80TQ2
MGI
1921506
GlyGen
Q80TQ2
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Z2F6 BCL3
0.667
5
UniProt:P68369 Tuba1a
6
AcK-TUBA1A [cytosol]
(R-MMU-5618312)
Ac K40 TUBA1A [axonemal microtubule]
(R-MMU-5624852)
L-isoglutamyl polyglycyl-TUBA1A [cytosol]
(R-MMU-8867428)
Polyglutamyl-TUBA1A [cytosol]
(R-MMU-8867408)
TUBA1A [axonemal microtubule]
(R-MMU-5610433)
Tubulin alpha-1A chain [cytosol]
(R-MMU-2316296)
0.558
5
UniProt:Q9Z2V5 Hdac6
3
HDAC6 [nucleoplasm]
(R-MMU-351589)
Hdac6 [cytosol]
(R-MMU-9646357)
HDAC6 [cytosol]
(R-MMU-5324660)
0.499
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text