Eif2ak3 phosphorylates Nfe2l2

Stable Identifier
R-MMU-9818776
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
3/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Eif2ak3 phosphorylates Nfe2l2
EIF2AK3 directly phosphorylates NFE2L2 and induces dissociation of KEAP1 from NFE2L2 thus inducing nuclear transport (Cullinan et al, 2003). This observation is primarily in mice but this regulation significance is well-reported in human diseases like AML (Jang et al, 2020).
Literature References
PubMed ID Title Journal Year
14517290 Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival

Kaufman, RJ, Zhang, D, Arvisais, E, Hannink, M, Diehl, JA, Cullinan, SB

Mol Cell Biol 2003
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Eif2ak3 [endoplasmic reticulum membrane]

Physical Entity
Eif2ak3 [endoplasmic reticulum membrane] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
EIF2AK3 phosphorylates NFE2L2 (Homo sapiens)
Authored
Tiwari, K  (2023-08-08)
Created
Tiwari, K  (2022-10-20)
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