Lef1:Ctnnb1, Nicd (Notch), and Tbx6 bind the Hes7 gene in presomitic mesoderm

Stable Identifier
R-MMU-9824206
Type
Reaction [binding]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Lef1:Ctnnb1, Nicd (Notch), and Tbx6 bind the Hes7 gene in presomitic mesoderm
Tbx6 binds two sites approximately 1.3 kb upstream of the transcription start site of Hes7 (González et al. 2013). Lef1:Ctnnb1 and the Notch intracellular domain (Nicd) complexed with Rbpj also bind within the upstream 2.6 kb of the Hes7 promoter and activate transcription (González et al. 2013).
Literature References
PubMed ID Title Journal Year
23326414 Control of Hes7 expression by Tbx6, the Wnt pathway and the chemical Gsk3 inhibitor LiCl in the mouse segmentation clock

Manosalva, I, Kageyama, R, Liu, T, González, A

PLoS One 2013
29895619 Presomitic mesoderm-specific expression of the transcriptional repressor Hes7 is controlled by E-box, T-box, and Notch signaling pathways

Nakahata, Y, Bessho, Y, Kohno, K, Matsui, T, Hayashi, S

J Biol Chem 2018
Participants
Orthologous Events
Authored
Reviewed
Created
Cite Us!