Reactome | Gdnf [extracellular region]

Gdnf [extracellular region]

Stable Identifier

R-MMU-9830758

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

Glial cell line-derived neurotrophic factor, GDNF_MOUSE

Locations in the PathwayBrowser

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Developmental Biology (Mus musculus)

- Nervous system development (Mus musculus)
  - Axon guidance (Mus musculus)
    - RET signaling (Mus musculus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB7,GRB10 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:PLCG1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:RET interactors [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SRC-1,RAP1GAP [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:DOK1,DOK2,DOK4,DOK5,DOK6 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - GDNF,NRTN bind RET:GFRA1,GFRA2 (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - PKA phosphorylates RET:GDNF:GFRA dimer (Mus musculus)
        
        2x RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - RET dimerizes (Mus musculus)
        
        2x RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - RET tyrosine phosphorylation (Mus musculus)
        
        2x RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - SHC1 in the RET complex is phosphorylated (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - p-5Y-RET complexes bind GRB2 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
      - p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)

Signal Transduction (Mus musculus)

- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - RAS GEFs promote RAS nucleotide exchange (Mus musculus)
        
        RAS GEFs [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Mus musculus)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Mus musculus)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Mus musculus)
        
        GDNF,NRTN [extracellular region] (Mus musculus)
        
        Gdnf [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:P48540 Gdnf

Gene Names

Gdnf

Chain

signal peptide:1-19, propeptide:20-75, chain:78-211

Reference Genes

BioGPS Gene:14573 Gdnf

KEGG:mmu:14573 Gdnf

Monarch:14573 Gdnf

NCBI Gene:14573 Gdnf

UCSC:P48540 Gdnf

Reference Transcript

Other Identifiers

10422844

1419080_at

14573

17310072

4324445

4324739

4378212

4646614

4794955

4830644

4841529

4857735

5060395

5070490

5512428

5573345

5614614

92738_at

A_51_P147777

A_55_P2045896

A_55_P2745662

GO:0001656

GO:0001657

GO:0001658

GO:0001755

GO:0001759

GO:0001941

GO:0003012

GO:0003337

GO:0005160

GO:0005576

GO:0005615

GO:0005794

GO:0006355

GO:0007169

GO:0007179

GO:0007399

GO:0007422

GO:0008083

GO:0008284

GO:0010468

GO:0021516

GO:0021784

GO:0030116

GO:0030154

GO:0030432

GO:0030971

GO:0031175

GO:0032770

GO:0035860

GO:0042803

GO:0043226

GO:0043524

GO:0045597

GO:0045944

GO:0048018

GO:0048255

GO:0048484

GO:0048485

GO:0048568

GO:0048731

GO:0048856

GO:0048870

GO:0051584

GO:0060676

GO:0060688

GO:0061024

GO:0071679

GO:0072107

GO:0072108

GO:0090190

GO:0098772

GO:1901166

GO:2001240

GO:2001260

ILMN_2659994

ILMN_2701617

mMC008169

u37459_s_at

Participates

as an output of

Expression of Gdnf in metanephric mesenchyme (Mus musculus)

as a component of

Gdnf:Ret:Gfra1 [plasma membrane] (Mus musculus)

as an input of

Gdnf from metanephric mesenchyme binds Ret:Gfra1 in the nephric duct (Mus musculus)

as a member of

GDNF,NRTN [extracellular region] (Mus musculus)

Inferred From

GDNF [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_001288286.1, NP_001288261.1, NP_034405.1

ENSEMBL

ENSMUSG00000022144, ENSMUST00000022744, ENSMUSP00000022744

PRO

P48540

GlyGen

P48540

MGI

107430

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