Expression of Sox2 in posterior neural plate

Stable Identifier
Reaction [omitted]
Mus musculus
SVG |   | PPTX  | SBGN
Expression of Sox2 in posterior neural plate
Prior to gastrulation, Sox2 is expressed throughout the epiblast (Wood and Episkopou 1999). During gastrulation, Sox2 becomes restricted to the presumptive neuroectoderm in the anterior ectoderm and persists in the neural plate and neural tube (Wood and Episkopou 1999, Avilion et al. 2003, Uchikawa et al. 2011, Iwafuchi-Doi et al. 2012). Sox2 is activated by the N1 enhancer in the posterior neural plate and by the N2 enhancer in the anterior neural plate. Wnt3a signaling and Fgf8 signaling originating from the chordoneural hinge activate the N1 enhancer, a conserved 420 bp sequence located downstream of the Sox2 coding region (Takemoto et al. 2006). As the node migrates posteriorly, other uncharacterized factors are believed to maintain Sox2 expression in the posterior neural plate.
Literature References
PubMed ID Title Journal Year
22992956 Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells

Aruga, J, Matsuda, K, Kondoh, H, Niwa, H, Tesar, PJ, Iwafuchi-Doi, M, Murakami, K, Matsuo, I

Development 2012
21762129 B1 and B2 Sox gene expression during neural plate development in chicken and mouse embryos: universal versus species-dependent features

Takemoto, T, Matsuda, K, Uchikawa, M, Kondoh, H, Iwafuchi-Doi, M, Ishida, Y, Yoshida, M

Dev Growth Differ 2011
10446282 Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages

Wood, HB, Episkopou, V

Mech Dev 1999
16354715 Convergence of Wnt and FGF signals in the genesis of posterior neural plate through activation of the Sox2 enhancer N-1

Takemoto, T, Uchikawa, M, Kondoh, H, Kamachi, Y

Development 2006
12514105 Multipotent cell lineages in early mouse development depend on SOX2 function

Perez, L, Nicolis, SK, Pevny, LH, Vivian, N, Lovell-Badge, R, Avilion, AA

Genes Dev 2003
This event is regulated
Negatively by
Orthologous Events
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