Expression of Gbx2 in posterior neural plate

Stable Identifier
R-MMU-9833045
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Gbx2 in posterior neural plate
Expression of Gbx2 in the posterior neural plate is strongly enhanced by Sox2, though it is unclear if Sox2 directly binds the Gbx2 gene (Iwafuchi-Doi et al. 2012, reviewed in Kondoh et al. 2016). Otx2 produced in the anterior neural plate is able to repress expression of Gbx2 even in the presence of Sox2 (Iwafuchi-Doi et al. 2012). The mutual antagonism of Gbx2 and Otx2 is believed to regulate midbrain and hindbrain patterning (Wassarman et al. 1997, Li and Joyner 2001, Martinez-Barbera et al. 2001, Wurst and Bally 2001).
Literature References
PubMed ID Title Journal Year
22992956 Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells

Aruga, J, Matsuda, K, Kondoh, H, Niwa, H, Tesar, PJ, Iwafuchi-Doi, M, Murakami, K, Matsuo, I

Development 2012
11731459 Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2

Schubert, F, Signore, M, Martinez-Barbera, JP, Lumsden, A, Puelles, E, Acampora, D, Gogoi, R, Boyl, PP, Simeone, A

Development 2001
Participants
Input
Output
This event is regulated
Negatively by
Regulator
Otx2 [nucleoplasm] (Mus musculus)
Positively by
Regulator
Sox2 [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of GBX2 in posterior neural plate (Homo sapiens)
Authored
May, B  (2023-04-12)
Reviewed
Kondoh, H  (2023-07-12)
Created
May, B  (2023-04-13)
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