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Sos1 [plasma membrane]
Stable Identifier
R-MMU-983559
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
SOS1, Q62245
Locations in the PathwayBrowser
Expand all
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)
BLNK (SLP-65) Signalosome [plasma membrane] (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Mus musculus)
Sos1 [plasma membrane] (Mus musculus)
BTK binds BTK inhibitors (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Mus musculus)
Sos1 [plasma membrane] (Mus musculus)
BTK:BTK inhibitors [plasma membrane] (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Mus musculus)
Sos1 [plasma membrane] (Mus musculus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Mus musculus)
Sos1 [plasma membrane] (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Mus musculus)
Sos1 [plasma membrane] (Mus musculus)
p-6Y-SYK phosphorylates BLNK (SLP65) (Mus musculus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Mus musculus)
Sos1 [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:Q62245 Sos1
Gene Names
Sos1
Chain
chain:1-1319
Reference Genes
BioGPS Gene:20662 Sos1
KEGG:mmu:20662 Sos1
Monarch:20662 Sos1
NCBI Gene:20662 Sos1
UCSC:Q62245 Sos1
Reference Transcript
RefSeq:NM_009231.2 Sos1
Other Identifiers
10453141
112449_at
1421884_at
1421885_at
1421886_at
1434389_at
160911_at
17347533
20662
4305177
4350021
4380164
4403196
4414894
4472863
4479945
4614931
4615682
4634565
4660293
4664066
4701723
4734575
4768134
4804663
4858618
4896441
4911288
4957355
4977665
5039201
5095191
5105634
5147425
5158144
5276979
5292116
5309269
5323713
5441405
5466247
5504101
5552064
A_51_P125792
A_52_P341339
A_55_P2935600
GE33702
GO:0001782
GO:0001942
GO:0002260
GO:0002376
GO:0002931
GO:0003007
GO:0003209
GO:0003344
GO:0005085
GO:0005154
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006355
GO:0006357
GO:0007173
GO:0007264
GO:0007265
GO:0007296
GO:0008286
GO:0008543
GO:0014044
GO:0014069
GO:0017124
GO:0019901
GO:0033081
GO:0035264
GO:0038133
GO:0042110
GO:0042127
GO:0042129
GO:0042552
GO:0043025
GO:0043226
GO:0045742
GO:0046579
GO:0046982
GO:0048009
GO:0048011
GO:0048514
GO:0048856
GO:0050853
GO:0051057
GO:0060021
GO:0060090
GO:0061029
GO:0061384
GO:0098772
GO:0098978
GO:0140693
GO:1904693
GO:1905360
GO:2000973
ILMN_2737338
Z11574_s_at
mMR029373
Participates
as a component of
p-BLNK:GRB2:SOS1:CIN85 [plasma membrane] (Mus musculus)
Other forms of this molecule
phospho-Sos1 [cytosol]
Sos1 [cytosol]
Sos1 [cytosol]
Inferred From
SOS1 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
NP_033257.2
ENSEMBL
ENSMUSP00000067786
,
ENSMUST00000068714
PRO
Q62245
MGI
98354
PDB
1B07
,
4GBQ
,
2GBQ
,
3GBQ
,
1PMS
,
1GBQ
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60631 Grb2
1
Grb2 [cytosol]
(R-MMU-443287)
0.757
7
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.704
4
UniProt:P62993-1 GRB2
2
GRB2-1 [cytosol]
(R-HSA-74686)
GRB2-1 [plasma membrane]
(R-HSA-202993)
0.558
2
UniProt:P26663 POLG
0.558
2
UniProt:P29355
1
sem-5 [cytosol]
(R-CEL-74686)
0.558
2
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