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APP [mitochondrial inner membrane]
Stable Identifier
R-MMU-9839060
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
mitochondrial inner membrane
Synonyms
P12023
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Mus musculus)
Mitochondrial protein degradation (Mus musculus)
HTRA2 degrades APP (Amyloid-beta precursor protein) (Mus musculus)
APP [mitochondrial inner membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:P12023
Reference Genes
BioGPS Gene:11820 APP
ENSEMBL:ENSMUSG00000022892
KEGG:mmu:11820 APP
Monarch:11820 APP
NCBI Gene:11820 APP
UCSC:P12023 APP
Reference Transcript
RefSeq:NM_001198823.1 APP
Participates
as an input of
HTRA2 degrades APP (Amyloid-beta precursor protein) (Mus musculus)
Other forms of this molecule
APP(672-713) [extracellular region]
APP(672-711) [extracellular region]
APP(18-770) [platelet alpha granule lumen]
APP(18-770) [extracellular region]
APP [endoplasmic reticulum lumen]
phospho-p-APP [endoplasmic reticulum lumen]
APP(18-770) [endosome lumen]
APP (535-695) [cytosol]
APP-C99 [cytosol]
APP(18-770) [trans-Golgi network membrane]
Inferred From
APP [mitochondrial inner membrane]
(Homo sapiens)
Cross References
RefSeq
NP_001185752.1
ENSEMBL
ENSMUST00000227723
,
ENSMUSG00000022892
,
ENSMUSP00000005406
,
ENSMUSP00000154061
,
ENSMUST00000005406
PRO
P12023
MGI
88059
GlyGen
P12023
PDB
2YT0
,
5MYK
,
7MRN
,
8S4Y
,
2YSZ
,
4YN0
,
2ROZ
,
8BG9
,
2YT1
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P97318
2
phospho-Dab1 [cytosol]
(R-MMU-8855227)
Dab1 [cytosol]
(R-MMU-8855236)
0.704
3
UniProt:Q03157 APLP1
0.667
4
UniProt:P14211 Calr
8
Calreticulin [extracellular region]
(R-MMU-3221763)
CALR [endocytic vesicle lumen]
(R-MMU-2239448)
CALR [extracellular region]
(R-MMU-2197641)
CALR [endoplasmic reticulum lumen]
(R-MMU-195905)
Calreticulin [phagocytic vesicle]
(R-MMU-1236838)
CALR [phagocytic vesicle membrane]
(R-MMU-1236879)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-MMU-8863866)
CALR [lumenal side of endoplasmic reticulum membrane]
(R-MMU-985502)
0.621
4
UniProt:Q9WVI9 JIP1
0.621
3
UniProt:Q06335
4
APLP2 [plasma membrane]
(R-MMU-8848902)
APLP2 [platelet alpha granule membrane]
(R-MMU-8848898)
phospho-p-APLP2 [endoplasmic reticulum lumen]
(R-MMU-8956977)
APLP2 [endoplasmic reticulum lumen]
(R-MMU-8956784)
0.609
3
UniProt:Q9EPL2 CSTN1
0.602
3
UniProt:Q9WVI9-1 MAPK8IP1
0.576
3
UniProt:P98084 APBA2
0.564
2
UniProt:O88307 SORL
0.557
3
UniProt:Q6PHU5
2
Sort1 [Golgi membrane]
(R-MMU-434332)
Sort1 [cytoplasmic vesicle membrane]
(R-MMU-434221)
0.518
3
UniProt:Q9QXJ1
1
Apbb1 [nucleoplasm]
(R-MMU-5683987)
0.508
2
UniProt:Q9UQF2 JIP1
0.508
2
UniProt:Q62108 Dlg4
3
SAP-90 [plasma membrane]
(R-MMU-443606)
Dlg4 [endocytic vesicle membrane]
(R-MMU-416847)
Dlg4 [cytosol]
(R-MMU-6794267)
0.499
4
UniProt:Q9QZS3 Numb
2
Numb [plasma membrane]
(R-MMU-2077469)
Numb [plasma membrane]
(R-MMU-443595)
0.471
2
UniProt:Q61477 NBL1
0.471
2
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